| Cloning of the rat insulin-like growth factor binding protein-1 gene and analysis of its 5' promoter region. | |
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MedLine Citation:
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PMID: 1378273 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To understand specific mechanisms involved in the regulation of insulin-like growth factor binding protein-1 (IGFBP-1), an important modulator of IGF bioactivity, we cloned the rat IGFBP-1 gene and sequenced a 1.5 kb Sph1-Sph1 fragment containing 1110 bases upstream from the translation start site. Computer analysis reveals the presence of ATA, CACCC, and CCAAT elements, and putative homeodomain, AP-1, insulin and glucocorticoid response elements in the 5' promoter. Primer extension and ribonuclease protection studies reveal a single cap site in RNA from rat hepatoma cells and both control and diabetic rat liver. |
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Authors:
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T G Unterman; R G Lacson; E McGary; C Whalen; C Purple; R G Goswami |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 185 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1992 Jun |
Date Detail:
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Created Date: 1992-08-07 Completed Date: 1992-08-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 993-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Illinois College of Medicine, Chicago. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Carrier Proteins / genetics* Cloning, Molecular DNA / genetics, isolation & purification Genes Genes, Homeobox Genes, Regulator Insulin-Like Growth Factor Binding Protein 1 Liver / metabolism Molecular Sequence Data Oligodeoxyribonucleotides Promoter Regions, Genetic* Rats Somatomedins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/Insulin-Like Growth Factor Binding Protein 1; 0/Oligodeoxyribonucleotides; 0/Somatomedins; 9007-49-2/DNA |
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