| Cloning of pediatric malignancies for drug sensitivity testing in the human tumor cloning assay. | |
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MedLine Citation:
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PMID: 3013039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a 4-year period 168 tumor specimens received from 119 pediatric patients were plated in a soft agar cloning system. Overall, 47 or 28% of the tumor specimens had growth adequate enough for drug sensitivity testing. Drug sensitivity testing was performed using a variety of standards as well as investigational anticancer agents. Overall, 129 evaluable in vitro drug sensitivity tests were performed with 33 (26%) of the tests showing sensitivity to an agent. The most active drugs in vitro included the standard agents doxorubicin and cis-platinum as well as the investigational agents mitoxantrone and m-AMSA. From these data it is clear the cloning assay can be used to study pediatric malignancies. However, before the cloning assay can be applied to clinical pediatric oncology practice, the assay must be improved in terms of tumor growth and validated with prospective clinical trials. |
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Authors:
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G L Morris; P M Zeltzer; S L Schneider; D D Von Hoff |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of pediatric hematology/oncology Volume: 8 ISSN: 0192-8562 ISO Abbreviation: Am J Pediatr Hematol Oncol Publication Date: 1986 |
Date Detail:
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Created Date: 1986-07-08 Completed Date: 1986-07-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7908071 Medline TA: Am J Pediatr Hematol Oncol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 52-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Antineoplastic Agents / therapeutic use* Brain Neoplasms / drug therapy Child Child, Preschool Colony-Forming Units Assay* / methods Humans Infant Infant, Newborn Kidney Neoplasms / drug therapy Lymphoma / drug therapy Neuroblastoma / drug therapy Sarcoma / drug therapy Tumor Stem Cell Assay* / methods Wilms Tumor / drug therapy |
| Grant Support | |
ID/Acronym/Agency:
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CA 27733-4/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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