Document Detail


Cloning of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene expressed specifically in testis.
MedLine Citation:
PMID:  16850186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Na+/H+ exchangers (NHEs) catalyze the transport of Na+ in exchange for H+ across membranes in organisms and are required for numerous physiological processes. Here we report the cloning and characterization of a novel human NHEDC1 (Na+/H+ exchanger like domain containing 1) gene, which was mapped to human chromosome 4p24. This cDNA is 1859 bp in length, encoding a putative protein of 515 amino acids. The NHEDC1 proteins are highly conserved in mammals including human, mouse, rat, and Macaca fascicularis. One remarkable characteristic of human NHEDC1 gene is that it is exclusively expressed in the testis by RT-PCR analysis. Western blot analysis showed that the molecular weight of NHEDC1 is about 56 KDa.
Authors:
Guangming Ye; Cong Chen; Dingding Han; Xiabin Xiong; Yahui Kong; Bo Wan; Long Yu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular biology reports     Volume:  33     ISSN:  0301-4851     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-12-22     Revised Date:  2011-11-03    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  IM    
Affiliation:
Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Base Sequence
Cell Line
Cloning, Molecular*
Gene Expression Regulation*
Humans
Male
Molecular Sequence Data
Organ Specificity
Sequence Alignment
Sodium-Hydrogen Antiporter / chemistry,  genetics*,  metabolism
Testis / metabolism*
Tissue Distribution
Transfection
Chemical
Reg. No./Substance:
0/SLC9B1 protein, human; 0/Sodium-Hydrogen Antiporter

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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