Document Detail


Cloning and linkage mapping of three polymorphic tetranucleotide (TAAA)n repeats on human chromosome 21.
MedLine Citation:
PMID:  1478649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the cloning, sequencing, and mapping of three short sequence repeat polymorphisms due to tetranucleotide (TAAA)n repeats from human chromosome 21. These DNA markers (D21S221, D21S225, D21S226) have been cloned from the chromosome 21-specific plasmid library of J. C. Fuscoe, C. C. Collins, D. Pinkel, and J. W. Gray (1989, Genomics 5: 100-109) and were shown to be polymorphic by polymerase chain reaction amplification and polyacrylamide gel electrophoresis. Genotypes were determined in informative CEPH pedigrees and used in linkage analysis relative to other mapped markers on human chromosome 21. One of these markers, D21S221, is closely linked to the amyloid precursor protein gene (APP), which has been implicated in the etiology of familial Alzheimer disease in some families.
Authors:
M Kalaitsidaki; T Cox; A Chakravarti; S E Antonarakis
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genomics     Volume:  14     ISSN:  0888-7543     ISO Abbreviation:  Genomics     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-10     Completed Date:  1993-02-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8800135     Medline TA:  Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1071-5     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/M88360;  M88361;  M88362;  M88363;  M88364;  M88365;  M88366;  M93145;  M93146;  M93147
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
Chromosomes, Human, Pair 21*
Cloning, Molecular
Female
Genetic Markers
Humans
Linkage (Genetics)*
Lod Score
Male
Molecular Sequence Data
Oligonucleotides / genetics*
Pedigree
Plasmids
Polymorphism, Genetic*
Repetitive Sequences, Nucleic Acid*
Grant Support
ID/Acronym/Agency:
HD-24605/HD/NICHD NIH HHS; HG-00373/HG/NHGRI NIH HHS
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/Oligonucleotides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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