| Cloning and characterization of CRF, a novel C1q-related factor, expressed in areas of the brain involved in motor function. | |
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MedLine Citation:
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PMID: 9878755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We have isolated and characterized a novel cDNA, C1q-Related Factor (CRF), that is predicted to encode a 258 amino acid polypeptide with a hydrophobic signal sequence, a collagenous region, and a globular domain at the carboxy terminus that shares homology to the C1q signature domain. Human CRF transcript is expressed at highest levels in the brain, particularly in the brainstem. In situ hybridization to mouse brain sections demonstrated that CRF transcripts are most abundant in areas of the nervous system involved in motor function, such as the Purkinje cells of the cerebellum, the accessory olivary nucleus, the pons and the red nucleus. The mouse CRF homolog is highly similar to the human gene at both the nucleotide and protein level, suggesting an important conserved role for this protein. |
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Authors:
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N G Bérubé; X H Swanson; M J Bertram; J D Kittle; V Didenko; D S Baskin; J R Smith; O M Pereira-Smith |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research. Molecular brain research Volume: 63 ISSN: 0169-328X ISO Abbreviation: Brain Res. Mol. Brain Res. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-02-19 Completed Date: 1999-02-19 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8908640 Medline TA: Brain Res Mol Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 233-40 Citation Subset: IM |
Copyright Information:
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Copyright 1999 Elsevier Science B.V. |
Affiliation:
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Roy M. and Phyllis Gough Huffington Center on Aging, Division of Molecular Virology, Departments of Cell Biology and Medicine, Baylor College of Medicine, One Baylor Plaza (M-320), Houston, TX 77030-3498, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Brain Chemistry / physiology* Cloning, Molecular Complement Activation* Complement C1q / isolation & purification* Humans Mice Molecular Sequence Data Motor Activity / physiology* Protein Biosynthesis RNA / biosynthesis Sequence Homology, Amino Acid |
| Grant Support | |
ID/Acronym/Agency:
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P01AG13663/AG/NIA NIH HHS; R37AG05333/AG/NIA NIH HHS; T32AG00183/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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63231-63-0/RNA; 80295-33-6/Complement C1q |
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