Document Detail

Cloning and characterisation of amphibian ClC-3 and ClC-5 chloride channels.
MedLine Citation:
PMID:  12421537     Owner:  NLM     Status:  MEDLINE    
Amphibians have provided important model systems to study transepithelial transport, acid-base balance and cell volume regulation. Several families of chloride channels and transporters are involved in these functions. The purpose of this review is to report briefly on some of the characteristics of the chloride channels so far reported in amphibian epithelia, and to focus on recently cloned members of the ClC family and their possible physiological roles. The electrophysiological characterisation, distribution, localisation and possible functions are reviewed and compared to their mammalian orthologs.
S Schmieder; S Lindenthal; J Ehrenfeld
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1566     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-07     Completed Date:  2003-01-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  55-66     Citation Subset:  IM    
Laboratoire de Physiologie des Membranes Cellulaires, Université de Nice-Sophia Antipolis, UMR 6078/CNRS, 284 Chemin du Lazaret, BP 68, Villefranche sur Mer, France.
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MeSH Terms
Cell Line
Chloride Channels / antagonists & inhibitors,  chemistry,  genetics*
Electric Conductivity
Epithelium / metabolism
Intestines / chemistry
Isotonic Solutions
Kidney / chemistry
Models, Animal
Oocytes / chemistry
Patch-Clamp Techniques
Rana esculenta
Skin / metabolism*
Sodium Chloride
Vacuolar Proton-Translocating ATPases / analysis
Xenopus laevis
Reg. No./Substance:
0/CLC-5 chloride channel; 0/Chloride Channels; 0/ClC-3 channel; 0/Isotonic Solutions; 7647-14-5/Sodium Chloride; 8026-10-6/Ringer's solution; EC 3.6.1.-/Vacuolar Proton-Translocating ATPases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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