| Clonidine provides opioid-sparing effect, stable hemodynamics, and renal integrity during laparoscopic cholecystectomy. | |
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MedLine Citation:
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PMID: 11727145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Carbon dioxide pneumoperitoneum causes a hemodynamic stress response and decreases urine output because of an activated renin-angiotensin-aldosterone system (RAAS). Clonidine is a potent antihypertensive drug that suppresses RAAS. METHODS: The effects of clonidine 4.5 mg/kg or saline on hemodynamics, neuroendocrine response, and renal parameters were compared in 30 healthy patients undergoing laparoscopic cholecystectomy. RESULTS: Heart rate, arterial blood pressures, and plasma renin activity were lower during and after pneumoperitoneum in patients with clonidine. There were no differences in urine output, urine oxygen tension (reflecting medullary perfusion), or antidiuretic hormone between the groups. N-acetyl-b-D-glucosaminidase, a marker of proximal tubular damage, was minimally elevated after clonidine. CONCLUSIONS: Clonidine enabled stable hemodynamics and prevented activation of RAAS seen as unchanged plasma renin activity. Clonidine may be beneficial during laparoscopy in patients with hypertension, cardiovascular, and/or renal diseases. |
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Authors:
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M Laisalmi; A M Koivusalo; P Valta; I Tikkanen; L Lindgren |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial Date: 2001-08-16 |
Journal Detail:
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Title: Surgical endoscopy Volume: 15 ISSN: 1432-2218 ISO Abbreviation: Surg Endosc Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-11-29 Completed Date: 2002-03-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8806653 Medline TA: Surg Endosc Country: Germany |
Other Details:
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Languages: eng Pagination: 1331-5 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia and Intensive Care Medicine, Surgical Hospital, Helsinki University Central Hospital, 00029 HUS Helsinki, Finland. merja.laisalmi@hus.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / administration & dosage Cholecystectomy, Laparoscopic / methods* Clonidine / administration & dosage* Double-Blind Method Heart Rate / drug effects Hemodynamics / drug effects* Humans Injections, Intramuscular Kidney Function Tests Middle Aged Pneumoperitoneum, Artificial / adverse effects Premedication Prospective Studies Renin / blood Renin-Angiotensin System / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 4205-90-7/Clonidine; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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