Document Detail

Clonidine provides an allergy-free alternative in glaucoma patients with proven allergy to apraclonidine.
MedLine Citation:
PMID:  10766284     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study was to determine allergic responses to clonidine hydrochloride 0.25% in glaucoma patients with proven allergic reaction to apraclonidine 0.5%. METHODS: Fifteen consecutive glaucoma patients with allergic reaction to apraclonidine were prospectively challenged with clonidine hydrochloride 0.25% and evaluated for recurrence of allergic reactions and efficacy of treatment. Intraocular pressure (IOP), conjunctival hyperemia, blood pressure and resting pulse rate were determined at baseline and after 1, 3, 6 and 12 months. RESULTS: None of the patients developed ocular allergic reaction during 12 months on clonidine therapy. Blood pressure and pulse rate did not change significantly with clonidine treatment. Clonidine caused a significant reduction of IOP from baseline. In one patient, topical clonidine caused fatigue, dizziness and dry mouth. CONCLUSION: Clonidine did not cause allergic reaction in patients with proven allergy to apraclonidine, indicating that there is no cross-reactivity with apraclonidine. Due to the small series, however, we cannot assume that allergy will not occur with clonidine 0.25% given time and a larger number of patients.
O Geyer; K G Schmidt; P Pianka; M Neudorfer; M Lazar
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  238     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-05-08     Completed Date:  2000-05-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  149-52     Citation Subset:  IM    
Department of Ophthalmology, Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
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MeSH Terms
Adrenergic alpha-Agonists* / administration & dosage,  adverse effects
Aged, 80 and over
Clonidine / administration & dosage,  adverse effects,  analogs & derivatives*,  therapeutic use*
Conjunctivitis, Allergic / chemically induced
Drug Hypersensitivity / etiology*
Exfoliation Syndrome / drug therapy*
Glaucoma, Open-Angle / drug therapy*
Intraocular Pressure / drug effects
Middle Aged
Ophthalmic Solutions
Treatment Outcome
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Ophthalmic Solutions; 4205-90-7/Clonidine; 66711-21-5/apraclonidine

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