Document Detail

Clonidine and modification of perioperative outcome.
MedLine Citation:
PMID:  16829723     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Perioperative cardiac risk reduction using perioperative beta-blockade is being widely adopted. Recent research has identified a second-line agent, perioperative clonidine, that can be used to reduce the risk of perioperative cardiac mortality. Perioperative clonidine has some advantages over perioperative beta-blockers because it has less risk of bronchospasm in asthmatics and it comes in a transcutaneous form that can be used in patients who are not taking oral medications ('NPO'). RECENT FINDINGS: Clonidine has been used for many purposes, including reduction of blood pressure in hypertension, reduction in alcohol and drug withdrawal phenomena, reduction in nicotine withdrawal symptoms during smoking cessation, analgesia, reduction in stress response, and now as an anti-ischemic agent to reduce the risk of perioperative myocardial ischemia and perioperative mortality. SUMMARY: Administration of perioperative clonidine can reduce the risk of perioperative myocardial ischemia and mortality in patients undergoing non-cardiac surgery. Perioperative clonidine comes in a patch form that can be used in patients who are not taking medications by mouth, and can be used when beta-blockers are contraindicated (for asthmatics or patients with high-grade atrioventricular block).
Arthur W Wallace
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in anaesthesiology     Volume:  19     ISSN:  0952-7907     ISO Abbreviation:  Curr Opin Anaesthesiol     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-07-10     Completed Date:  2006-11-30     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  8813436     Medline TA:  Curr Opin Anaesthesiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  411-7     Citation Subset:  IM    
Department of Anesthesia and Perioperative Care, University of California, San Francisco, California, USA.
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MeSH Terms
Adrenergic alpha-Agonists / therapeutic use*
Clonidine / therapeutic use*
Cost-Benefit Analysis
Pain, Postoperative / drug therapy
Perioperative Care*
Risk Management
Treatment Outcome
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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