Document Detail


Clonidine-induced vasoconstriction in awake volunteers.
MedLine Citation:
PMID:  11473842     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IMPLICATIONS: IV clonidine, at doses that decrease blood pressure, causes arterial vasoconstriction in awake subjects. These data suggest that an alpha-2 agonist with a high alpha-2a/alpha-2b selectivity should provide more profound sedative and analgesic effects with less undesirable vasoconstrictive effects.
Authors:
P O Talke; E P Lobo; R Brown; C A Richardson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  93     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-08-16     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  271-6, 1st contents page     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia and Perioperative Medicine, University of California, San Francisco, CA 94143-0648, USA. talkep@anesthesia.ucsf.edu
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology*
Adult
Blood Pressure / drug effects
Clonidine / pharmacology*
Female
Humans
Male
Skin / blood supply
Skin Temperature / drug effects
Vasoconstriction / drug effects*
Wakefulness
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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