Document Detail


Clonidine effect on spasticity: a clinical trial.
MedLine Citation:
PMID:  3348719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clonidine was used as an adjunct to baclofen in 55 patients with spasticity due to spinal cord injury. Dosage was held at the minimum effect amount for those who responded. No effect was seen in 24 patients (44%), although 31 (56%) benefitted from the drug. Patients were grouped as quadriplegics or paraplegics, having complete or incomplete lesions. Of all quadriplegics, seven of 11 complete (64%) and 17 of 25 incomplete patients (68%) responded; among the paraplegics, six of 15 complete (40%) and one of four incomplete patients (25%) improved. Side effects were limited to postural hypotension necessitating reduction in dosage in three patients that were successfully treated; in the unsuccessfully treated group, one patient had insomnia, one had dizziness, and one had drowsiness.
Authors:
W H Donovan; R E Carter; C D Rossi; M A Wilkerson
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  69     ISSN:  0003-9993     ISO Abbreviation:  Arch Phys Med Rehabil     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-12     Completed Date:  1988-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  193-4     Citation Subset:  AIM; IM    
Affiliation:
Institute for Rehabilitation and Research, Houston, TX 77030.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Clonidine / adverse effects,  therapeutic use*
Female
Humans
Male
Middle Aged
Muscle Spasticity / drug therapy*,  etiology
Paraplegia / complications
Spinal Cord Injuries / complications
Chemical
Reg. No./Substance:
4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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