Document Detail


Clonidine attenuated early proinflammatory response in T-cell subsets after cardiac surgery.
MedLine Citation:
PMID:  17000786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
T-cells play a central role in the immune response to injury. Cardiac surgery is associated with significant risk of systemic inflammatory response syndrome and subsequent unbalanced induction of proinflammatory cytokines. As clonidine has immunomodulating properties via reducing sympathetic activity, this study involved the analysis of T-cell function in the early postoperative period in patients undergoing coronary artery bypass graft surgery. Forty patients undergoing cardiac surgery were randomly allocated to one of the following groups: clonidine group (n = 20) [clonidine 1 microg kg(-1) h(-1)] and placebo group (n = 20). Study medication was started after induction of anesthesia and maintained until 6 h after surgery. Blood samples to determine Th1 and Th2 cells and cytotoxic lymphocytes (Tc1 and Tc2 cells) were drawn preoperatively, on admission to the intensive care unit, 6 and 12 h postoperatively as well as on the morning of days 1 and 2 after surgery. In the clonidine group significantly lower levels of Th1/Th2 ratios as well as Tc1/Tc2 ratios were found 6 h postoperatively compared to the placebo group (P < 0.05). Clonidine changed the ratio of T-lymphocyte subpopulations in peripheral blood in favor of a proinflammatory response, which might be favorable for maintaining immune balance after surgery.
Authors:
Vera von Dossow; Nadine Baehr; Maryam Moshirzadeh; Christian von Heymann; Jan P Braun; Ortrud V Hein; Michael Sander; Klaus-D Wernecke; Wolfgang Konertz; Claudia D Spies
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  103     ISSN:  1526-7598     ISO Abbreviation:  Anesth. Analg.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-26     Completed Date:  2006-10-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  809-14     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesiology and Intensive Care Medicine, Campus Virchow-Klinikum and Campus Charité Mitte, Charité, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / pharmacology
Aged
Analgesics / pharmacology*
Clonidine / pharmacology*
Coronary Artery Bypass / adverse effects,  methods*
Double-Blind Method
Female
Hemodynamics / drug effects
Humans
Male
Middle Aged
Placebos
Prospective Studies
T-Lymphocyte Subsets / drug effects*,  immunology
T-Lymphocytes, Cytotoxic / drug effects,  immunology
Th1 Cells / drug effects,  immunology
Th2 Cells / drug effects,  immunology
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Analgesics; 0/Placebos; 4205-90-7/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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