Document Detail

Clonidine as pre-anesthetic medication in cataract extraction: comparison between 100 microg and 200 microg.
MedLine Citation:
PMID:  20011859     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVES: The objective of the present study was to evaluate the degree of sedation, intraocular pressure, and hemodynamic changes with premedication with low doses of oral clonidine, 100 microg and 200 microg, in outpatient cataract surgeries.
METHODS: This is a randomized, double-blind, clinical study undertaken at the Universidade Federal de São Paulo with 60 patients of both genders, physical status ASA 1 and 2, ages 18 to 80 years. Patients were separated into three groups: placebo, clonidine 100 microg, and clonidine 200 microg. Intraocular pressure, heart rate, and blood pressure besides assessment of sedation were measured before and 90 minutes after the administration of clonidine. Sedation levels were classified according to the Ramsay sedation scale.
RESULTS: Patients who received placebo and 100 microg of clonidine did not show reduction in heart rate, while a reduction in heart rate was observed in patients who received 200 microg of clonidine, and this difference was statistically significant. Patients who received 200 microg of clonidine also had a reduction in systolic and diastolic blood pressure (p < 0.05). One patient who received 200 microg of clonidine developed severe hypotension, with systolic pressure < 80 mmHg. Patients treated with clonidine had a reduction in intraocular pressure (p < 0.05). Ninety minutes after the oral administration of placebo and 100 microg and 200 microg of clonidine, 25%, 60%, and 80% of the patients respectively were classified as Ramsay 3 or 4.
CONCLUSIONS: Clonidine 100 microg can be indicated as premedication for fasciectomies, being effective in sedation and reduction of intraocular pressure, without adverse effects on blood pressure and heart rate.
José Roquennedy Souza Cruz; Denise Ferreira Barroso de Melo Cruz; Bruno Castelo Branco; Ana Ellen de Queiroz Santiago; José Luiz Gomes do Amaral
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Revista brasileira de anestesiologia     Volume:  59     ISSN:  1806-907X     ISO Abbreviation:  Rev Bras Anestesiol     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-12-17     Completed Date:  2010-04-22     Revised Date:  2014-02-05    
Medline Journal Info:
Nlm Unique ID:  0401316     Medline TA:  Rev Bras Anestesiol     Country:  Brazil    
Other Details:
Languages:  eng; por     Pagination:  694-703     Citation Subset:  IM    
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MeSH Terms
Analgesics / administration & dosage*
Cataract Extraction*
Clonidine / administration & dosage*
Double-Blind Method
Middle Aged
Preanesthetic Medication*
Reg. No./Substance:
0/Analgesics; MN3L5RMN02/Clonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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