Document Detail

Clonidine as a pre-anesthetic agent for flexible bronchoscopy.
MedLine Citation:
PMID:  15303639     Owner:  NLM     Status:  MEDLINE    
Several drugs have been employed for sedation during flexible fiberoptic bronchoscopy (FOB). Clonidine attenuates stress-induced sympathoadrenal responses and has sedative properties. We investigate the effects of clonidine premedication on hemodynamic and comfort parameters of patients submitted to FOB under airway topical anesthesia only. Patients received placebo (n = 22; men = 16; median age = 50.5 years) or intravenous clonidine (3 microg/kg; n = 20; men = 15; median age = 46.0 years) 15 min before FOB. Blood pressure (BP), heart rate (HR), plasma norepinephrine (nor) and cortisol levels were measured before, during, and 1 h after FOB. Comfort was assessed by the examiner and by the patients using a visual numerical scale (0-10). The placebo group showed significant increases in systolic BP, HR, and nor levels during FOB (SBP = 125 mmHg x 145 mmHg; HR = 74 bpm x 85 bpm; nor = 316.2 pg/dl x 483.1 pg/dl), whereas clonidine group did not display such changes. Clonidine group showed a lower frequency of cardiac arrhythmias than the placebo group during and after FOB (supraventricular = 39% x 50%; ventricular = 22% x 40%). Levels of comfort were high and comparable in both groups. We concluded that although clonidine led to a somewhat better hemodynamic profile, it did not contribute to better comfort in this setting.
Adriana Inacio de Padua; Margareth de Castro; André Schmidt; Joaquim Coutinho Neto; João Terra Filho; José Antônio Baddini Martinez
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Respiratory medicine     Volume:  98     ISSN:  0954-6111     ISO Abbreviation:  Respir Med     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-08-11     Completed Date:  2004-11-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8908438     Medline TA:  Respir Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  746-51     Citation Subset:  IM    
Internal Medicine Department, Medical School of Ribeirão Preto, University of São Paulo, Brazil.
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MeSH Terms
Blood Pressure / drug effects
Bronchoscopy / methods*
Double-Blind Method
Heart Rate / drug effects
Hydrocortisone / blood
Middle Aged
Pain / prevention & control
Preanesthetic Medication / methods*
Reg. No./Substance:
0/Analgesics; 0/Sympatholytics; 4205-90-7/Clonidine; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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