| Clonidine antagonizes the aversive effects of opiate withdrawal and the rewarding effects of morphine only in opiate withdrawn rats. | |
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MedLine Citation:
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PMID: 8731065 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The researchers asked whether clonidine, an alpha 2-noradrenergic agonist, would block selectively the motivational effects of opiate withdrawal and whether clonidine's effects would respect the boundary between nondeprived and deprived motivational states. In a place conditioning paradigm, clonidine (0.05 mg/kg ip) blocked the rewarding effects of morphine in opiate-withdrawn rats (as well as the aversive properties of withdrawal itself), but did not affect morphine place preferences (2 and 20 mg/kg) in drug-naive rats. Furthermore, clonidine blocked the acquisition of morphine (15 mg/kg), but not LiCl (15 mg/kg), conditioned taste aversions in water-deprived rats. The results suggest that the motivational system activated in deprived animals includes dopaminergic and noradrenergic components that are in series with each other. |
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Authors:
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K Nader; D van der Kooy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Behavioral neuroscience Volume: 110 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-10-02 Completed Date: 1996-10-02 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 389-400 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, University of Toronto, Canada. K. nader@utoronoto.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology* Animals Arousal / drug effects*, physiology Association Learning / drug effects, physiology Avoidance Learning / drug effects, physiology Clonidine / pharmacology* Conditioning, Classical / drug effects*, physiology Dose-Response Relationship, Drug Lithium Chloride / pharmacology Male Mental Recall / drug effects, physiology Morphine / pharmacology* Morphine Dependence / physiopathology* Motivation* Norepinephrine / physiology* Rats Rats, Wistar Social Environment Substance Withdrawal Syndrome / physiopathology* Taste / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 4205-90-7/Clonidine; 51-41-2/Norepinephrine; 57-27-2/Morphine; 7447-41-8/Lithium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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