| Clonazepam responsive opsoclonus myoclonus syndrome: additional evidence in favour of fastigial nucleus disinhibition hypothesis? | |
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MedLine Citation:
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PMID: 20094737 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Opsoclonus myoclonus syndrome is a rare paraneoplastic syndrome seen in 50% of children with neuroblastoma. Neural generator of opsoclonus and myoclonus is not known but evidences suggest the role of fastigial nucleus disinhibition from the loss of function of inhibitory (GABAergic) Purkinje cells in the cerebellum. We present a child with paraneoplastic opsoclonus myoclonus syndrome who responded well to clonazepam. Response to clonazepam is an evidence for the involvement of GABAergic neural circuits in the genesis of opsoclonus myoclonus syndrome and is in agreement with fastigial nucleus disinhibition hypothesis. |
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Authors:
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Vimal Kumar Paliwal; Satish Chandra; Ritu Verma; Jayantee Kalita; Usha K Misra |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-01-22 |
Journal Detail:
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Title: Journal of neural transmission (Vienna, Austria : 1996) Volume: 117 ISSN: 1435-1463 ISO Abbreviation: J Neural Transm Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9702341 Medline TA: J Neural Transm Country: Austria |
Other Details:
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Languages: eng Pagination: 613-5 Citation Subset: IM |
Affiliation:
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Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. dr_vimalkpaliwal@rediffmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autoantibodies
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metabolism Cerebellar Cortex / immunology, metabolism, physiopathology Cerebellar Nuclei / drug effects*, metabolism, physiopathology* Clonazepam / administration & dosage* Efferent Pathways / immunology, metabolism, physiopathology GABA Modulators / administration & dosage Humans Infant Male Neural Inhibition / drug effects*, physiology Neuroblastoma / complications, immunology, surgery Neurosurgical Procedures Opsoclonus-Myoclonus Syndrome / drug therapy*, metabolism, physiopathology* Pelvic Neoplasms / complications, immunology, surgery Purkinje Cells / immunology, metabolism, pathology Treatment Outcome gamma-Aminobutyric Acid / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/GABA Modulators; 1622-61-3/Clonazepam; 56-12-2/gamma-Aminobutyric Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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