Document Detail

Clonality of Endocrine Proliferative Lesions: A Critical Reappraisal.
MedLine Citation:
PMID:  12114775     Owner:  NLM     Status:  Publisher    
The distinction between nodular hyperplasia and benign tumors of the endocrine system is problematical. Although numerous parameters including lesional size, multicentricity and histological features have been suggested as distinguishing criteria, none of these is absolute. Analyses based on X-chromosome inactivation have provided conflicting results with respect to the clonal origins of these lesions, and at least some lesions conventionally classified as hyperplastic nodules appear to be monoclonal, Although clonality has been generally equated with neoplasia, it is likely that clonal expansion of genetically normal cells can occur in the endocrine system as a result of a variety of growth of promoting stimuli. Multiparametric studies employing markers for X-chromosome inactivation together with methods for identification of unique non-X-linked genetic alterations will be required to resolve the many questions relating to the pathogenesis of endocrine proliferative lesions.
Ronald A. DeLellis; Arthur S. Tischler
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Publication Detail:
Journal Detail:
Title:  Endocrine pathology     Volume:  9     ISSN:  1559-0097     ISO Abbreviation:  Endocr. Pathol.     Publication Date:  1998  
Date Detail:
Created Date:  2002-Jul-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009288     Medline TA:  Endocr Pathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  281-285     Citation Subset:  -    
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