Document Detail

Clonal status and clinicopathological features of Langerhans cell histiocytosis.
MedLine Citation:
PMID:  20819448     Owner:  NLM     Status:  MEDLINE    
Some studies have demonstrated that Langerhans cell histiocytosis (LCH) is a neoplastic hyperplasia of Langerhans cells, however some researchers consider that clonality should be assessed in more patients with LCH, both at disease presentation and during the disease course. Monoclonality is a major characteristic of most tumours, whereas normal tissue and reactive hyperplasia are polyclonal. To elucidate the nature of Langerhans cells further, the present study investigated the clinicopathological features and clonality of three cases of LCH in female patients using laser microdissection and a clonality assay, based on X-chromosomal inactivation mosaicism in somatic tissues and polymorphism of the androgen receptor gene. The results indicated that LCH was composed of Langerhans cells with a characteristic morphological appearance, eosinophils, giant cells, neutrophils and foamy cells. Immunohistochemically, the Langerhans cells were positive for CD1a, S-100 protein and vimentin. The clonality assay demonstrated that the Langerhans cells formed a monoclonal population, showing that LCH is neoplastic. We conclude that LCH is characterized by clonal proliferation, although additional studies with larger sample sizes are required to prove this conclusively.
L Gong; W-D Zhang; Y-H Li; X-Y Liu; L Yao; X-J Han; S-J Zhu; M Lan; W Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of international medical research     Volume:  38     ISSN:  0300-0605     ISO Abbreviation:  J. Int. Med. Res.     Publication Date:    2010 May-Jun
Date Detail:
Created Date:  2010-09-07     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346411     Medline TA:  J Int Med Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1099-105     Citation Subset:  IM    
Department of Pathology, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
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MeSH Terms
Chromosomes, Human, X / genetics
Clone Cells
DNA, Neoplasm
Fluorescent Antibody Technique, Indirect
Histiocytosis, Langerhans-Cell / genetics*,  metabolism,  pathology*
Immunoenzyme Techniques
Langerhans Cells / metabolism,  pathology*
Polymorphism, Genetic
Receptors, Androgen / genetics
X Chromosome Inactivation
Reg. No./Substance:
0/DNA, Neoplasm; 0/Receptors, Androgen

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