Document Detail

Clonal heterogeneity in physiological properties of melanized cells induced from goldfish erythrophoroma cell lines.
MedLine Citation:
PMID:  6468803     Owner:  NLM     Status:  MEDLINE    
Cells of the uncloned goldfish erythrophoroma lines, GEM-81 and GEM-218, have been induced to melanize by cultivation in autologous serum. The melanized cells continue to proliferate and exhibit clonal heterogeneity in terms of morphology, growth rates, contact behavior and pigment content, and distribution and translocation in response to hormones. Based on these characteristics and those of their normal counterparts, the melanized tumor cells have been categorized as type-I and type-II melanocytomas, and melanophoromas. The melanophoroma cells are capable of pigment translocation in response to epinephrine, melatonin, and/or MSH, whereas melanocytoma cells are not. The distinguishing characteristics of each type are apparent at the first appearance of melanized cells and appear to be stable except in some type-II melanocytoma clones which contain cells capable of differentiating into melanophoroma cells in long-term cultures. It appears that the parent erythrophoroma lines contain stem cells, melanoblastomas, which are capable of melanogenesis. These stem cells may themselves be a heterogeneous population with respect to the characteristics of the melanized cells to which they give rise.
J Matsumoto; T Ishikawa; P Masahito; S Takayama; J D Taylor; T T Tchen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Differentiation; research in biological diversity     Volume:  27     ISSN:  0301-4681     ISO Abbreviation:  Differentiation     Publication Date:  1984  
Date Detail:
Created Date:  1984-09-28     Completed Date:  1984-09-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0401650     Medline TA:  Differentiation     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  36-45     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation / drug effects
Cell Line
Clone Cells / pathology
Cyprinidae / physiology*
Epinephrine / pharmacology
Goldfish / physiology*
Melanocyte-Stimulating Hormones / pharmacology
Melanoma / pathology*
Melanophores / ultrastructure
Melatonin / pharmacology
Neoplasms, Experimental / pathology
Skin Neoplasms / pathology,  veterinary*
Skin Pigmentation* / drug effects
Grant Support
Reg. No./Substance:
51-43-4/Epinephrine; 73-31-4/Melatonin; 9002-79-3/Melanocyte-Stimulating Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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