Document Detail


Clonal heterogeneity in mycosis fungoides and its relationship to clinical course.
MedLine Citation:
PMID:  12384439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mycosis fungoides (MF) is a cutaneous T-cell lymphoma characterized by multifocal disease and protracted clinical course. The few studies that have assessed T-cell receptor (TCR) gene rearrangements (GRs) present at different anatomic sites in MF have generally reported a common clone. We used a previously validated 4-color polymerase chain reaction (PCR) assay to assess the size and V-family usage of TCR-gamma GRs in 102 concurrent and/or sequential morphologically involved biopsy specimens (91 skin and 11 lymph nodes) from 39 MF patients. This assay detected TCR-gamma clonal GRs in 89 samples (87%) from 36 patients (92%). In 24 patients (77%), an identical clonal GR was present in at least 2 skin samples. However, in one third of these patients, additional different clonal GRs were also noted. Four patients (13%) had clonal GRs that were distinct in different skin samples. In 3 patients (10%), no GR was detected in any sample. In a comparison of lymph node and skin samples, 8 patients had the identical clonal GRs at both sites, 2 patients had different clonal GRs, and 1 patient had no GR identified at either site. Independent of clinical stage, patients who had the same GR detected in multiple concurrent biopsy specimens at the time of diagnosis were more likely to have progressive disease than those who had different GRs (P =.04). Four-color TCR-gamma PCR analysis can uncover multiple distinct clonal GRs in different samples consistent with multiclonal or oligoclonal disease in a significant proportion of MF patients. Demonstration of identical clonal GRs in multiple biopsy specimens at the time of diagnosis may provide prognostic information related to disease progression.
Authors:
Francisco Vega; Rajyalakshmi Luthra; L Jeffrey Medeiros; Valerie Dunmire; Sang-Joon Lee; Madeleine Duvic; Dan Jones
Related Documents :
16603099 - Cutaneous manifestations in a patient with a long-term history of untreated acth-depend...
20952999 - Vesicular and bullous eruptions in tropical (filarial) eosinophilia.
831239 - Lower blepharoplasty--a clinical study.
6490979 - Cancer of the skin in blacks. iii. a review of nineteen black patients with bowen's dis...
10337669 - Dermatologic findings in anorexia and bulimia nervosa of childhood and adolescence.
7665319 - Prevalence of skin and genital mucous membrane irritations in patients confined to bed.
24515929 - Trunk restraint to promote upper extremity recovery in stroke patients: a systematic re...
3340399 - Tarsorrhaphy for corneal disease in patients with rheumatoid arthritis.
19752449 - Seizure frequency and lateralization affect progression of atrophy in temporal lobe epi...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Blood     Volume:  100     ISSN:  0006-4971     ISO Abbreviation:  Blood     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-17     Completed Date:  2002-12-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7603509     Medline TA:  Blood     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3369-73     Citation Subset:  AIM; IM    
Affiliation:
Division of Pathology and Laboratory Medicine, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Biopsy
Child
Clone Cells / pathology
Disease Progression
Female
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor*
Humans
Lymph Nodes / pathology
Male
Middle Aged
Mycosis Fungoides / genetics,  pathology*
Neoplasm Proteins / genetics
Neoplastic Stem Cells / chemistry,  pathology*
Polymerase Chain Reaction / methods*
Prognosis
Receptors, Antigen, T-Cell, gamma-delta / genetics
Skin / pathology
Grant Support
ID/Acronym/Agency:
CA 16672/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Neoplasm Proteins; 0/Receptors, Antigen, T-Cell, gamma-delta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary m...
Next Document:  The Src homology 2 domain-containing inositol 5-phosphatase negatively regulates Fcgamma receptor-me...