| Clonal expansion in B-CLL: fungal drivers or self-service? | |
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MedLine Citation:
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PMID: 23319726 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Relatively few cancers arise in mature, differentiated cells. The propensity of mature B cells to transform has been linked to their longevity and proliferative potential, and stimulation of the B cell receptor (BCR) by cognate antigen may promote the transformation process. A study in this issue (Hoogeboom et al.) lends support to this notion, showing that cancer cells from a subset of patients with chronic lymphocytic leukemia (CLL) express a BCR specific for a sugar expressed by commensal yeast species. Another study, in contrast, suggests that B-CLL cells uniquely acquire the ability to signal in the complete absence of ligand. |
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Authors:
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Mel Greaves |
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Publication Detail:
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Type: Comment; Journal Article; Review |
Journal Detail:
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Title: The Journal of experimental medicine Volume: 210 ISSN: 1540-9538 ISO Abbreviation: J. Exp. Med. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-15 Completed Date: 2013-04-12 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 2985109R Medline TA: J Exp Med Country: United States |
Other Details:
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Languages: eng Pagination: 1-3 Citation Subset: IM |
Affiliation:
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Division of Molecular Pathology, Institute of Cancer Research, Sutton, Surrey SM2 5NG, England, UK. mel.greaves@icr.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Epitopes
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metabolism* Humans Leukemia, Lymphocytic, Chronic, B-Cell / genetics* Receptors, Antigen, B-Cell / genetics*, metabolism* Yeasts / metabolism* beta-Glucans / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Epitopes; 0/Receptors, Antigen, B-Cell; 0/beta-Glucans; 37361-00-5/beta-1,6-glucan |
| Comments/Corrections | |
Comment On:
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J Exp Med. 2013 Jan 14;210(1):59-70
[PMID:
23296468
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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