Document Detail

Clonal evolution in chronic myelogenous leukemia.
MedLine Citation:
PMID:  15271399     Owner:  NLM     Status:  MEDLINE    
Clonal evolution (CE) may be a marker of disease progression in chronic myelogenous leukemia (CML) and is thought to reflect the genetic instability of the highly proliferative CML progenitors. The frequency of CE increases with advancing stage, rising from 30%in accelerated phase and up to 80% in blast crisis. Given its association with disease progression, CE is considered a feature that defines accelerated-phase CML; however, not all studies have demonstrated a uniformly poor outcome for patients with CE. Chromosomal abnormalities in Ph chromosome negative metaphases increasingly have been recognized in patients treated with imatinib. The true incidence of this phenomenon is not clear but appears to occur in 2% to 17% of imatinib-treated patients. Regardless of the precise mechanism and the long-term clinical implications, the findings described in this article underscore the importance of routine cytogenetic analysis for patients treated with imatinib. The continued study of these phenomena will help us to understand better the pathogenesis of CML and improve the long-term treatment of patients with CML.
Jorge Cortes; Michael E O'Dwyer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hematology/oncology clinics of North America     Volume:  18     ISSN:  0889-8588     ISO Abbreviation:  Hematol. Oncol. Clin. North Am.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-07-23     Completed Date:  2004-09-23     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8709473     Medline TA:  Hematol Oncol Clin North Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  671-84, x     Citation Subset:  IM    
Department of Leukemia, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 428, Houston, TX 77030, USA.
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MeSH Terms
Antineoplastic Agents / pharmacology,  therapeutic use
Chromosome Aberrations
Clone Cells / drug effects,  pathology
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy,  mortality,  pathology*
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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