| Clonal development and karyotype evolution during leukemogenesis of BCR/ABL transgenic mice. | |
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MedLine Citation:
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PMID: 1737087 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Philadelphia (Ph) translocation is responsible for the generation of the chimeric BCR/ABL oncogene. The Ph chromosome constitutes the earliest detectable chromosome abnormality in chronic myelogenous leukemia and is also found in acute lymphoblastic leukemia. Mice transgenic for a P190 BCR/ABL-producing DNA construct develop lymphoblastic leukemia/lymphoma and provide an opportunity to study early stages of the disease as well as progression. In this study, we have karyotyped the bone marrow of 10 19-day-old BCR/ABL P190 transgenic mice from a line that reproducibly develops leukemia/lymphoma. Leukemic cells from 17 terminally ill transgenic founders and progeny were also karyotyped as well as bone marrow transplant recipients of leukemic donor marrow. Karyotypically visible aberrations were absent from the early stages of BCR/ABL P190-generated leukemia and normal metaphases could be found even in the terminal stages of the disease. A high frequency of aneuploidy was found in advanced leukemia, with a marked preference for the gain of mouse chromosomes 12, 14, or 17. These results point to a primary role for BCR/ABL in leukemogenesis and suggest a destabilizing effect of the BCR/ABL gene on the regulation of cell division. |
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Authors:
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J W Voncken; C Morris; P Pattengale; G Dennert; C Kikly; J Groffen; N Heisterkamp |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Blood Volume: 79 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-03-16 Completed Date: 1992-03-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1029-36 Citation Subset: AIM; IM |
Affiliation:
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Department of Pathology, Childrens Hospital of Los Angeles 90027. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy Animals Blotting, Southern Bone Marrow Transplantation Chromosome Aberrations* Clone Cells DNA / analysis Fusion Proteins, bcr-abl / genetics* Karyotyping Leukemia, Experimental / genetics* Lymphoma / genetics* Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic |
| Grant Support | |
ID/Acronym/Agency:
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CA47073/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fusion Proteins, bcr-abl; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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