Document Detail


Clonal cell populations unresponsive to radiosensitization induced by telomerase inhibition.
MedLine Citation:
PMID:  20875790     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A combination of a radiotherapeutic regimen with telomerase inhibition is valuable when tumor cells are to be sensitized to radiation. Here, we describe cell clones unresponsive to radiosensitization after telomere shortening. After extensive division of individual transformed clones of mTERC-/- cells, about 22% of clones were unresponsive to radiosensitization even though telomerase action was inhibited. The telomere lengths of unsensitized mTERC-/- clones were reduced, as were those of most sensitized clones. However, the unsensitized clones did not exhibit chromosomal end-to-end fusion to the extent noted in all sensitized clones. Thus, a defense mechanism preventing telomere erosion is operative even when telomeres become shorter under conditions of telomerase deficiency, and results in unresponsiveness to the radiosensitization generally mediated by telomere shortening.
Authors:
Yeun-Jin Ju; Hyun-Jin Shin; Jeong-Eun Park; Kyoung-Mi Juhn; Seon Rang Woo; Hee-Young Kim; Young-Hoon Han; Sang-Gu Hwang; Sung-Hee Hong; Chang-Mo Kang; Young-Do Yoo; Won-Bong Park; Myung-Haing Cho; Gil Hong Park; Kee-Ho Lee
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-26
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  402     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-15     Completed Date:  2010-12-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  198-202     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Division of Radiation Cancer Research, Korea Institute of Radiological & Medical Sciences, Seoul 139-706, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Animals
Clone Cells
Fibroblasts / enzymology,  radiation effects
Mice
Mice, Mutant Strains
Radiation Tolerance*
Telomerase / antagonists & inhibitors*,  genetics
Telomere / metabolism*
Chemical
Reg. No./Substance:
EC 2.7.7.49/Telomerase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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