Document Detail

Clonal T-helper lymphocytes and elevated IL-5 levels in episodic angioedema and eosinophilia (Gleich's syndrome).
MedLine Citation:
PMID:  14565669     Owner:  NLM     Status:  MEDLINE    
A patient with marked chronic eosinophilia and episodic angioedema (Gleich's syndrome) with a concomitant clonal proliferation of helper T-lymphocytes is described. This association has not previously been documented. The symptoms and clinical course differ markedly from the idiopathic hypereosinophilic syndrome, including an absence of end organ involvement. However, the disease appears to have a similar pathogenesis, with elevated levels of the eosinophil-specific cytokine interleukin-5 (IL-5) produced by the T-cell clone.
Susan J Morgan; H Miles Prince; David A Westerman; Christopher McCormack; Ian Glaspole
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  44     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-10-20     Completed Date:  2004-03-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  England    
Other Details:
Languages:  eng     Pagination:  1623-5     Citation Subset:  IM    
Department of Haematology, Peter MacCallum Cancer Institute, East Melbourne, Vic., Australia.
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MeSH Terms
Angioedema / etiology*
Clone Cells / pathology
Diagnosis, Differential
Eosinophilia / blood,  complications*,  diagnosis,  immunology,  pathology
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
Hypereosinophilic Syndrome / diagnosis
Interleukin-5 / blood*
Middle Aged
Paraproteins / analysis*
T-Lymphocytes, Helper-Inducer / pathology*
Reg. No./Substance:
0/Interleukin-5; 0/Paraproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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