Document Detail

Clonal Identity and Differences in Primary Cutaneous B-Cell Lymphoma Occurring at Different Sites or Time Points in the Same Patient.
MedLine Citation:
PMID:  22588547     Owner:  NLM     Status:  Publisher    
ABSTRACT:: Primary cutaneous B-cell lymphomas (PCBCL) are rare. Marginal zone lymphomas and follicle center lymphomas (FCL) represent a majority of these cases, and a significant number of cases present with multiple lesions. It is unclear whether multiple lesions in PCBCL represent dissemination of a single clone or multiple new primary lymphomas. In the current study, we analyzed paired samples from 20 PCBCL patients at more than 1 site (16) or at the same site at different time points (4) and 12 patients with benign lymphoid infiltrates to investigate for the presence or absence of a clone, and if present, whether the clones were identical. Both IGH@ and IGK@ rearrangements were tested using the BIOMED-2 protocol. We identified a clone (IGH@ and/or IGK@) in 19 of 20 (95%) PCBCL patients and 2 of 12 (17%) benign lymphoid infiltrate patients. The B-cell clones were proven to be identical in 11 of 20 (55%) PCBCL patients, including 7 of 16(44%) biopsies from patients with 2 different sites and 4 of 4 biopsies (100%) from patients at the same site but different time points. In 4 cases (3 FCL and 1 marginal zone lymphoma), different clones were detected at different sites, suggesting the possibility of a second simultaneous primary lymphoma. Our results indicate that the presence of identical clones is highly suggestive of lymphoma. To our knowledge, this is the first report to investigate the detection of identical clones in 2 distinct biopsies in PCBCL patients. Although the study is small and the results need to be confirmed in a larger study, these findings suggest that a subset of PCBCL at different sites may represent different primary tumors rather than occurrence of a single disease.
Mika Fujiwara; Anjali V Morales; Katie Seo; Youn H Kim; Daniel A Arber; Uma N Sundram
Related Documents :
18086997 - The risk of mortality in patients with psoriasis: results from a population-based study.
6211147 - Patch tests with killed sonicated microflora in patients with psoriasis.
20354857 - Sacroiliac joint involvement in psoriasis.
14726967 - Ocular anterior segment pathologies and tear film changes in patients with psoriasis vu...
21372547 - Serum and saliva sialic acid in periodontitis patients with and without cardiovascular ...
11154777 - Apolipoprotein e varepsilon4 allele has an impact on vascular reactivity in alzheimer's...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-14
Journal Detail:
Title:  The American Journal of dermatopathology     Volume:  -     ISSN:  1533-0311     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911005     Medline TA:  Am J Dermatopathol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of *Pathology †Dermatology, Stanford University Medical Center, Stanford, CA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Malignant Melanoma Within Squamous Cell Carcinoma and Basal Cell Carcinoma: Is it a Combined or Coll...
Next Document:  A Clinicopathologic and Molecular Biologic Study of Patients Presenting With Few Adnexal Tumors (Two...