| Clofibrate for unconjugated hyperbilirubinemia in neonates: a systematic review. | |
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MedLine Citation:
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PMID: 22318100 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effect of clofibrate for unconjugated hyperbilirubinemia in neonates. METHODS: A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibrate treatment in neonates with unconjugated hyperbilirubinemia. We followed the guidelines from the Cochrane review group and the PRISMA statement. RESULTS: Of 148 studies identified, a total of 13 studies on 867 infants were included. A single oral administration of clofibrate was associated with decreased need of phototherapy (RR:.38, 95% CI: 0.21 to 0.68), shortened duration of phototherapy (mean duration: 23.88 h, 95% CI: 33.03 to -14.72 h) and reduced peak total serum bilirubin (mean duration: -1.62 mg/dL, 95% CI: 2.13 to -1.11 mg/dL). These effects were especially obvious in term infants and infants without hemolytic diseases. Data regarding mortality or kernicterus were not available from included studies. CONCLUSIONS: Clofibrate may have short-term benefits for the infants with hyperbilirubinaemia, especially for population of term infants and infants without hemolytic diseases. Large RCTs with long-term followup are required to verify the safety of clofibrate and assess its long-term effects. |
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Authors:
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Tao Xiong; Dapeng Chen; Zhoujin Duan; Yi Qu; Dezhi Mu |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Indian pediatrics Volume: 49 ISSN: 0974-7559 ISO Abbreviation: Indian Pediatr Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-02-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985062R Medline TA: Indian Pediatr Country: India |
Other Details:
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Languages: eng Pagination: 35-41 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China and *Department of Neurology and Pediatrics, Newborn Brain Research Institute, University of California, San Francisco, California, USA. Correspondence to: Dezhi Mu, Department of Pediatrics, West China Second University Hospital, Sichuan University, China. dezhi.mu@ucsf.edu. |
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