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Clofibrate for unconjugated hyperbilirubinemia in neonates: a systematic review.
MedLine Citation:
PMID:  22318100     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
OBJECTIVE: To evaluate the effect of clofibrate for unconjugated hyperbilirubinemia in neonates.
METHODS: A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibrate treatment in neonates with unconjugated hyperbilirubinemia. We followed the guidelines from the Cochrane review group and the PRISMA statement.
RESULTS: Of 148 studies identified, a total of 13 studies on 867 infants were included. A single oral administration of clofibrate was associated with decreased need of phototherapy (RR:.38, 95% CI: 0.21 to 0.68), shortened duration of phototherapy (mean duration: 23.88 h, 95% CI: 33.03 to -14.72 h) and reduced peak total serum bilirubin (mean duration: -1.62 mg/dL, 95% CI: 2.13 to -1.11 mg/dL). These effects were especially obvious in term infants and infants without hemolytic diseases. Data regarding mortality or kernicterus were not available from included studies.
CONCLUSIONS: Clofibrate may have short-term benefits for the infants with hyperbilirubinaemia, especially for population of term infants and infants without hemolytic diseases. Large RCTs with long-term followup are required to verify the safety of clofibrate and assess its long-term effects.
Authors:
Tao Xiong; Dapeng Chen; Zhoujin Duan; Yi Qu; Dezhi Mu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian pediatrics     Volume:  49     ISSN:  0974-7559     ISO Abbreviation:  Indian Pediatr     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-02-09     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985062R     Medline TA:  Indian Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  35-41     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China and *Department of Neurology and Pediatrics, Newborn Brain Research Institute, University of California, San Francisco, California, USA. Correspondence to: Dezhi Mu, Department of Pediatrics, West China Second University Hospital, Sichuan University, China. dezhi.mu@ucsf.edu.
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