| Clofarabine, Cyclophosfamide, and Etoposide for the Treatment of Relapsed or Resistant Acute Leukemia in pediatric patients. | |
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MedLine Citation:
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PMID: 22303898 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT Clofarabine is a promising, new chemotherapeutic agent that is active in the treatment of pediatric acute leukemia. Forty children ( 16 AML, 24 ALL), aged 1-20 years (median 7.6 years) with relapsed or refractory Acute Lymphoblastic Leukemia (ALL) or Acute Myeloid Leukemia (AML) were treated because of resistance to first line treatment (5) , or for first (22) , second (11), or third relapse (2) . They received clofarabine (40 mg/m(2)/day) associated with etoposide (100 mg/m(2)/day) and Cyclophosphamide (440 mg/m(2)/day) administered as 1 or 2 induction cycles (5 days of chemotherapy) in an attempt to reach complete remission (CR) or CR without platelet recovery (CRp). This was followed by 1 to 3 consolidation cycles (4 days of chemotherapy) for a maximum of 4 cycles. Seven (44%) out of 16 and 10 (42%) out of 24 evaluable children with AML and ALL respectively, responded to treatment. The most common adverse events were infections and gastrointestinal and hepatic toxicity. Thirteen (76%) out of 17 responders underwent SCT. 24-month OS was 25%, while it was 59% among patients who responded to the first induction cycle. Our study suggests that this drug regimen is well tolerated and can be effective in heavily pretreated relapsed or refractory pediatric patients with acute leukemia. |
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Authors:
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Miano M; Pistorio A; Putti Mc; Dufour C; Messina C; Barisone E; Ziino O; Parasole R; Luciani M; Lonigro L; G de Rossi; Varotto S; Bertorello N; Petruzziello F; Calvillo M; Micalizzi C |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-6 |
Journal Detail:
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Title: Leukemia & lymphoma Volume: - ISSN: 1029-2403 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007422 Medline TA: Leuk Lymphoma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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