| Clocks not winding down: unravelling circadian networks. | |
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MedLine Citation:
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PMID: 20966970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An intrinsic clock enables an organism to anticipate environmental changes and use energy sources more efficiently, thereby conferring an adaptive advantage. Having an intrinsic clock to orchestrate rhythms is also important for human health. The use of systems biology approaches has advanced our understanding of mechanistic features of circadian oscillators over the past decade. The field is now in a position to develop a multiscale view of circadian systems, from the molecular level to the intact organism, and to apply this information for the development of new therapeutic strategies or for enhancing agricultural productivity in crops. |
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Authors:
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Eric E Zhang; Steve A Kay |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Nature reviews. Molecular cell biology Volume: 11 ISSN: 1471-0080 ISO Abbreviation: Nat. Rev. Mol. Cell Biol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-22 Completed Date: 2010-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962782 Medline TA: Nat Rev Mol Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 764-76 Citation Subset: IM |
Affiliation:
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Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive-0130, La Jolla, California 92093-0130, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Clocks / genetics* CLOCK Proteins / genetics Circadian Rhythm / genetics* Energy Metabolism / genetics* Gene Expression Profiling Gene Regulatory Networks* Humans Models, Genetic |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM056006/GM/NIGMS NIH HHS; R01 GM067837/GM/NIGMS NIH HHS; R01 GM074868/GM/NIGMS NIH HHS; R01 GM092412/GM/NIGMS NIH HHS; R01 MH051573/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 2.3.1.48/CLOCK Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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