Document Detail

Clobazam for the treatment of intractable epilepsy in children.
MedLine Citation:
PMID:  23112242     Owner:  NLM     Status:  MEDLINE    
We describe our experience using clobazam, examining efficacy for individual seizure types and analyzing for factors contributing to initial and sustained response. We retrospectively reviewed medical charts of children treated with clobazam. We collected patient and treatment characteristics and compared response to therapy at 6, 12, and >12 months' duration. One hundred eight patients with a variety of seizure types and etiologies of epilepsy were treated. Response rates for >50% seizure reduction were 59%, 39%, and 30% of patients at 6, 12, and >12 months' therapy, respectively. No seizure type responded more favorably and there were no patient predictors of favorable response. Patients tended to respond early and at low dosing, and half the patients maintained this response for 15 months or more. Clobazam has efficacy against a wide spectrum of seizure types and epilepsy etiologies. An early, low-dose response is a favorable indicator for sustained response.
M Scott Perry; Laurie Bailey; Saleem Malik; Courtney Gilson; Amy Kotecha; Angel Hernandez
Publication Detail:
Type:  Journal Article     Date:  2012-10-30
Journal Detail:
Title:  Journal of child neurology     Volume:  28     ISSN:  1708-8283     ISO Abbreviation:  J. Child Neurol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-06-04     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  8606714     Medline TA:  J Child Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-9     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / therapeutic use*
Benzodiazepines / therapeutic use*
Child, Preschool
Epilepsy / classification,  drug therapy*,  etiology
Follow-Up Studies
Kaplan-Meier Estimate
Retrospective Studies
Reg. No./Substance:
0/Anticonvulsants; 12794-10-4/Benzodiazepines; 2MRO291B4U/clobazam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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