| Clitocybins, novel isoindolinone free radical scavengers, from mushroom Clitocybe aurantiaca inhibit apoptotic cell death and cellular senescence. | |
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MedLine Citation:
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PMID: 19801829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High concentration of intracellular reactive oxygen species (ROS) plays a role in damaging biological systems. We isolated clitocybin A from the culture broth of Clitocybe aurantiaca and then clitocybin B and C derivatives were synthesized from clitocybin A. IMR-90 lung fibroblast cells were pre-treated or post-treated with clitocybin A, B and C to the addition of 100 muM H(2)O(2). These compounds inhibited the level of intracellular reactive oxygen species (ROS) and H(2)O(2)-induced cell death as judged by hypodiploid cell formation. The inhibitory effect of clitocybins on H(2)O(2)-induced cell death was comparable to that with N-acetylcysteine (NAC), a well-known ROS scavenger. The inhibition of H(2)O(2)-induced cell death by clitocybins was mediated by the reduction of caspase 3 and 9 activation, cytochrome c release from mitochondria and the degradation of IkappaB-alpha and IkappaB-beta, which could be resulted in the prevention of cellular senescence. It suggests that clitocybins are novel compounds scavenging ROS and protect cells from apoptosis and cellular senescence. |
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Authors:
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Eun-Yi Moon; Jin-Mi Oh; Young-Hee Kim; In-Ja Ryoo; Ick-Dong Yoo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biological & pharmaceutical bulletin Volume: 32 ISSN: 1347-5215 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
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Languages: eng Pagination: 1689-94 Citation Subset: IM |
Affiliation:
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Department of Bioscience and Biotechnology, Sejong University, 98 Kunja-Dong Kwangjin-Gu, Seoul 143-747, Republic of Korea. eunyimoon@sejong.ac.kr |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcysteine
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pharmacology Agaricales* Apoptosis / drug effects* Caspase 3 / metabolism Caspase 9 / metabolism Cell Aging / drug effects* Cell Line Cytochromes c / metabolism Free Radical Scavengers / chemical synthesis, pharmacology* Fungal Proteins / chemical synthesis, pharmacology* Humans Hydrogen Peroxide I-kappa B Proteins / metabolism Isoindoles / chemical synthesis, chemistry, isolation & purification, pharmacology* Mitochondria / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Free Radical Scavengers; 0/Fungal Proteins; 0/I kappa B beta protein; 0/I-kappa B Proteins; 0/Isoindoles; 0/clitocybin A; 0/clitocybin B; 0/clitocybin C; 139874-52-5/NF-kappaB inhibitor alpha; 616-91-1/Acetylcysteine; 7722-84-1/Hydrogen Peroxide; 9007-43-6/Cytochromes c; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspase 9 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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