Document Detail


Clioquinol treatment in familiar early onset of Alzheimer's disease: a case report.
MedLine Citation:
PMID:  16025421     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recently the metal chelator clioquinol (CQ) has been suggested as a possible option for treatment of Alzheimer's disease (AD). We report two patients with early onset of AD [one with a mutant amyloid-precursor-protein (APP) gene] who received long-term treatment with CQ. In both cases focally augmented cerebral glucose metabolism and stabilization but no amelioration of the clinical impression were observed without signs of neurotoxicity. In one case CSF-tau and beta-Amyloid (42/40) concentrations changed during CQ treatment.
Authors:
B Ibach; E Haen; J Marienhagen; G Hajak
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pharmacopsychiatry     Volume:  38     ISSN:  0176-3679     ISO Abbreviation:  Pharmacopsychiatry     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2005-08-26     Revised Date:  2006-08-10    
Medline Journal Info:
Nlm Unique ID:  8402938     Medline TA:  Pharmacopsychiatry     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  178-9     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstrasse 84, Regensburg, Germany. bernd.ibach@klinik.uni-regensburg.de
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / drug therapy*,  metabolism,  psychology
Amyloid beta-Protein / metabolism
Brain / pathology
Chelating Agents / adverse effects,  therapeutic use*
Clioquinol / adverse effects,  therapeutic use*
Cognition / drug effects,  physiology
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Neuropsychological Tests
Risk Assessment
tau Proteins / cerebrospinal fluid
Chemical
Reg. No./Substance:
0/Amyloid beta-Protein; 0/Chelating Agents; 0/tau Proteins; 130-26-7/Clioquinol
Comments/Corrections
Comment In:
Pharmacopsychiatry. 2006 Mar;39(2):80   [PMID:  16555171 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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