Document Detail

Clinicopathological study of originally non-lupus "full-house" nephropathy.
MedLine Citation:
PMID:  20863204     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Glomerular "full-house" immunofluorescence staining commonly indicates lupus nephritis. However, some non-lupus nephropathy also can present with a "full-house" immunofluorescence pattern mimicking lupus nephritis. The goal of this study is to define the clinicopathological spectrum of originally non-lupus "full-house" nephropathy.
METHODS: Records of 24 patients with "full-house" nephropathy in the absence of clinical or serological evidence of systemic lupus erythematosus (SLE) at the time of renal biopsy were abstracted for demographics, clinical presentation, laboratory data, renal biopsy findings, and clinical follow-up.
RESULTS: The clinicopathological diagnoses included membranous glomerulonephritis (GN) (46%), IgA nephropathy (21%), membranoproliferative GN (12.5%), postinfectious GN (12.5%), C1q nephropathy (4%), and unclassified mesangial GN (4%). No one had endothelial tubuloreticular inclusions. One patient originally diagnosed as IgA nephropathy developed anti-DNA antibody and another one patient with membranous GN developed hypocomplementemia 8 months and 10 months after renal biopsy, respectively. The two patients also developed clinical symptoms of lupus subsequently.
CONCLUSIONS: There was a broad spectrum of glomerular histological findings in non-lupus "full-house" nephropathy. The possibility of "full-house" nephropathy preceding the emergence of overt systemic lupus erythematosus remained to be elucidated.
Yao-Ko Wen; Mei-Ling Chen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  32     ISSN:  1525-6049     ISO Abbreviation:  Ren Fail     Publication Date:  2010  
Date Detail:
Created Date:  2010-09-24     Completed Date:  2011-01-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  England    
Other Details:
Languages:  eng     Pagination:  1025-30     Citation Subset:  IM    
Division of Nephrology, Changhua Christian Medical Center, Changhua, Taiwan.
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MeSH Terms
Glomerulonephritis / epidemiology,  pathology*
Kidney / pathology*
Lupus Nephritis
Middle Aged
Retrospective Studies
Taiwan / epidemiology
Young Adult

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