Document Detail

Clinicopathological study of bilateral developmental cataracts diagnosed in utero.
MedLine Citation:
PMID:  16028026     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We report a case of unusual, bilateral developmental cataracts in a fetus with a supernumerary chromosome. METHODS: A 42-year-old woman presented during her 6th pregnancy for assessment of fetal karyotype. This showed a supernumerary chromosome derived from chromosome 21. Subsequently fetal ultrasound suggested the presence of bilateral cataracts and the pregnancy was terminated at 19 weeks and 3 days' gestation. Both eyes were submitted for histopathological and electron microscopical examination. RESULTS: Histopathological examination revealed unusual bilateral developmental cataracts with abnormal bladder-type cells lining the posterior aspect of the lens vesicle, a poorly formed nuclear bow and a central mass of fibrillar material associated with macrophages lying within an area of liquefaction. Transmission electron microscopy revealed the presence of peg and socket joints in both central and posterior regions and degenerate crystallins in the posterior region. CONCLUSIONS: We described an unusual case of developmental cataract diagnosed in utero by ultrasound. The morphological appearances suggest that the defect occurred during or after formation of the secondary lens fibres. Detailed descriptions of cases such as this one may contribute to our understanding of lens development and cataract formation.
Fiona Roberts; Stephen Wisdom; Allan G Howatson; Stuart Imrie
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2005-07-19
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  244     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-23     Completed Date:  2007-05-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  237-42     Citation Subset:  IM    
University Department of Pathology, Western Infirmary, Dumbarton Road, Glasgow, G11 6NT, Scotland, UK.
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MeSH Terms
Abortion, Legal
Cataract / embryology*,  genetics,  pathology*,  ultrasonography
Chromosome Aberrations / embryology*
Chromosomes, Human, Pair 21 / genetics*
Gestational Age
In Situ Hybridization, Fluorescence
Lens, Crystalline / pathology*
Ultrasonography, Prenatal

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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