Document Detail

Clinicopathological and immunohistochemical features of the severe pulmonary form of leptospirosis.
MedLine Citation:
PMID:  12170336     Owner:  NLM     Status:  MEDLINE    
Four cases of severe pulmonary form of leptospirosis (SPFL) are described. In all four of these blood culture proven cases, there was severe pulmonary injury characterized by alveolar hemorrhage and acute respiratory failure. Three patients died in less than 48 hours after onset of the first respiratory signs. Leptospiral antigen detection in lung tissues was positive by immunoperoxidase in all three of these cases, suggesting that the microorganism exerts a local direct destructive action. Patients with SPFL should be carefully monitored, as the abrupt onset of severe alveolar hemorrhage can lead to respiratory insufficiency and death. The authors emphasize the importance of radiological findings and blood gas analysis for prompt clinical diagnosis, and suggest that corticosteroids, associated with antibiotics, early respiratory support, and platelet transfusions are useful as an attempt to prevent further development of SPFL.
João José Pereira Silva; Marcos Olivier Dalston; Jorge Eduardo Manhães Carvalho; Sérgio Setúbal; Janice Mery Chiarino Oliveira; Martha Maria Pereira
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Revista da Sociedade Brasileira de Medicina Tropical     Volume:  35     ISSN:  0037-8682     ISO Abbreviation:  Rev. Soc. Bras. Med. Trop.     Publication Date:    2002 Jul-Aug
Date Detail:
Created Date:  2002-08-09     Completed Date:  2002-12-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7507456     Medline TA:  Rev Soc Bras Med Trop     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  395-9     Citation Subset:  IM    
Disciplina de Doenças Infecciosas e Parasitária, Departamento de Medicina Clínica, Faculdade de Medicina, Universidade Federal Fluminense, Niterói, RJ.
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MeSH Terms
Fatal Outcome
Leptospirosis* / complications,  pathology
Lung Diseases / complications,  microbiology*,  pathology
Respiratory Insufficiency / microbiology*,  pathology

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