Document Detail

Clinicopathological and immunohistochemical features of oral spindle cell carcinoma.
MedLine Citation:
PMID:  20002980     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Oral spindle cell carcinoma (SpCC) is a rare variant of oral squamous cell carcinoma (SCC). The aims of this study were to compare the clinicopathologic and immunohistochemical features of oral SpCC with conventional oral SCC. METHODS: Five cases of oral SpCC and 10 cases of oral SCC (five well-differentiated and five poorly differentiated) were evaluated through conventional hematoxylin and eosin staining and immunohistochemical reactions to cytokeratins (CK), vimentin, desmin, smooth muscle actin, muscle-specific actin, S-100 protein, epithelial membrane antigen (EMA), p53, and ki-67. RESULTS: Oral SpCC showed predilection for males on their sixth decade of life, presenting clinically as painful infiltrative ulcers or ulcerated exophytic polypoid masses, preferably located on the alveolar mucosa. Mesenchymal markers were expressed in the spindle cell but not in the carcinomatous component of SpCC, and it was negative in all SCC. CKs AE1/AE3, 6, 14, and EMA were positive on both carcinomatous and spindle cell components of most SpCCs. These tumors also presented higher p53 and ki-67 expression and no CK 1 expression in contrast to well-differentiated SCC. CONCLUSION: Oral SpCC presented a different clinical profile than conventional SCC and histopathologic features and p53 and ki-67 expression closer to poorly differentiated SCC. Besides mesenchymal markers, CK AE1/AE3, 6, 14, and EMA expression on spindle cells may be useful as an adjunct on microscopical differential diagnosis of SpCC.
Mário José Romañach; Rebeca Souza Azevedo; Roman Carlos; Oslei Paes de Almeida; Fábio Ramôa Pires
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-03
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  39     ISSN:  1600-0714     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-21     Completed Date:  2010-09-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  335-41     Citation Subset:  D; IM    
Oral Pathology, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil.
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MeSH Terms
Actins / analysis
Age Factors
Carcinoma / pathology*
Carcinoma, Squamous Cell / pathology
Desmin / analysis
Keratin-13 / analysis
Keratin-14 / analysis
Keratin-6 / analysis
Keratin-8 / analysis
Keratins / analysis
Ki-67 Antigen / analysis
Middle Aged
Mouth Neoplasms / pathology*
Mucin-1 / analysis
S100 Proteins / analysis
Sex Factors
Tumor Suppressor Protein p53 / analysis
Vimentin / analysis
Reg. No./Substance:
0/Actins; 0/Desmin; 0/Keratin-13; 0/Keratin-14; 0/Keratin-6; 0/Keratin-8; 0/Ki-67 Antigen; 0/Mucin-1; 0/S100 Proteins; 0/Tumor Suppressor Protein p53; 0/Vimentin; 68238-35-7/Keratins

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