Document Detail

Clinicopathological and immunohistochemical analysis of spindle-cell carcinoid tumour of the lung.
MedLine Citation:
PMID:  22034892     Owner:  NLM     Status:  MEDLINE    
AIMS: To analyse the clinicopathological features and immunohistchemical profile of spindle-cell carcinoid tumours (SCCT) of the lung.
METHODS AND RESULTS: Using a cut-off value of ≥ 50% spindle cells for defining SCCT, 13 were indentified among 80 consecutively resected carcinoid cases. SCCTs are asymptomatic and are peripherally located, well-demarcated tumours. Tumour cells were composed of elongated spindle cells, with scant to moderate amounts of cytoplasm and uniform nuclei with fine granular chromatin. Immunohistochemical analysis revealed that all 13 cases were positive for three neuroendocrine markers (chromogranin A, synaptophysin and CD56). Four tumours (30.7%) were positive for broad-spectrum cytokeratin (CK) and nine tumours (69.2%) were positive for thyroid transcription factor 1. All epithelial components were negative for vimentin, but 12 tumours (92.3%) were positive for stellate-shaped cells (so-called sustentacular cells).
CONCLUSIONS: SCCTs are clinically asymptomatic, peripherally located, well-demarcated tumours, and patients with SCCTs have a favourable outcome. The immunoreactivity pattern of SCCT (low reactivity of broad-spectrum CK and reactivity for vimentin in intratumoral sustentacular cells) might result in a misdiagnosis of SCCT as mesenchymal tumour; therefore, pathologists need to be familiar with this pattern.
Koji Tsuta; Neda Kalhor; Ignacio I Wistuba; Cesar A Moran
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Histopathology     Volume:  59     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-31     Completed Date:  2012-02-17     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  526-36     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Limited.
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MeSH Terms
Carcinoid Tumor / metabolism,  mortality,  pathology*
Kaplan-Meier Estimate
Lung Neoplasms / metabolism,  mortality,  pathology*
Middle Aged
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/Tumor Markers, Biological
Erratum In:
Histopathology. 2011 Dec;59(6):1283

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