| Clinicopathological and immunohistochemical analysis of spindle-cell carcinoid tumour of the lung. | |
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MedLine Citation:
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PMID: 22034892 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS AND RESULTS: Using a cut-off value of ≥ 50% spindle cells for defining SCCT, 13 were indentified among 80 consecutively resected carcinoid cases. SCCTs are asymptomatic and are peripherally located, well-demarcated tumours. Tumour cells were composed of elongated spindle cells, with scant to moderate amounts of cytoplasm and uniform nuclei with fine granular chromatin. Immunohistochemical analysis revealed that all 13 cases were positive for three neuroendocrine markers (chromogranin A, synaptophysin and CD56). Four tumours (30.7%) were positive for broad-spectrum cytokeratin (CK) and nine tumours (69.2%) were positive for thyroid transcription factor 1. All epithelial components were negative for vimentin, but 12 tumours (92.3%) were positive for stellate-shaped cells (so-called sustentacular cells). CONCLUSIONS: SCCTs are clinically asymptomatic, peripherally located, well-demarcated tumours, and patients with SCCTs have a favourable outcome. The immunoreactivity pattern of SCCT (low reactivity of broad-spectrum CK and reactivity for vimentin in intratumoral sustentacular cells) might result in a misdiagnosis of SCCT as mesenchymal tumour; therefore, pathologists need to be familiar with this pattern. |
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Authors:
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Koji Tsuta; Neda Kalhor; Ignacio I Wistuba; Cesar A Moran |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Histopathology Volume: 59 ISSN: 1365-2559 ISO Abbreviation: Histopathology Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-10-31 Completed Date: 2012-02-17 Revised Date: 2013-05-20 |
Medline Journal Info:
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Nlm Unique ID: 7704136 Medline TA: Histopathology Country: England |
Other Details:
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Languages: eng Pagination: 526-36 Citation Subset: IM |
Copyright Information:
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© 2011 Blackwell Publishing Limited. |
Affiliation:
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Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoid Tumor / metabolism, mortality, pathology* Female Humans Immunohistochemistry Kaplan-Meier Estimate Lung Neoplasms / metabolism, mortality, pathology* Male Middle Aged Prognosis Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Tumor Markers, Biological |
| Comments/Corrections | |
Erratum In:
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Histopathology. 2011 Dec;59(6):1283 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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