Document Detail

Clinicopathological and immunocytochemical study of multifocal epithelial hyperplasia.
MedLine Citation:
PMID:  17954316     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We present the clinicopathological findings after reviewing 52 patients affected by multifocal epithelial hyperplasia (MEH), previously known as focal epithelial hyperplasia and the results of an immunocytochemical study. PATIENTS AND METHODS: We reviewed the clinical files and microscopic slides from 52 MEH-affected patients and new slides were immunostained with a polyclonal antibody against high molecular weight cytokeratins. RESULTS: More than 95% of the patients were in poverty (<200 dollars monthly family income). Females comprised 71.1% of the MEH patients, 69.3% were in the first and second decades and buccal mucosa, lips, and tongue were more frequently affected. Ninety-two percent of the patients had a direct relative with similar lesions. In hematoxylin and eosin-stained slides, prominent multiple nucleoli were observed. Immunocytochemical study showed differences in immunostaining between lesional and normal cells. Cells with strongly immunostained cytoplasm were seen in the prickle layer of the lesional epithelium as well as in the clinically normal neighboring epithelial tissue. Cytokeratin-negative mitosis-like cells and koilocytes were identified within the lesions. CONCLUSIONS: The name "multifocal epithelial hyperplasia" is more accurate than those previously proposed designations, because it is more precise to describe the clinical and microscopic features of the disease. Also, our results suggest that mitosis-like cells and koilocytes are degenerated cells unable to synthesize cytokeratins and that cells with strongly immunostained cytoplasm represent epithelial cells showing an altered cytokeratin metabolic profile.
Constantino Ledesma-Montes; Maricela Garcés-Ortíz; Juan Carlos Hernández-Guerrero
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons     Volume:  65     ISSN:  0278-2391     ISO Abbreviation:  J. Oral Maxillofac. Surg.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-23     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8206428     Medline TA:  J Oral Maxillofac Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2211-7     Citation Subset:  AIM; D; IM    
Clinical Oral Pathology Laboratory, Facultad de Odontología, Universidad Nacional Autónoma de México, Ciudad Universitaria, Mexico City, Mexico.
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MeSH Terms
Age Factors
Cell Nucleolus / ultrastructure
Child, Preschool
Cytoplasm / ultrastructure
Epithelial Cells / pathology
Focal Epithelial Hyperplasia / pathology*
Keratins / analysis*
Lip Diseases / pathology
Mexico / ethnology
Middle Aged
Mouth Mucosa / pathology
Retrospective Studies
Sex Factors
Social Class
Tongue Diseases / pathology
Reg. No./Substance:

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