| Clinicopathological findings of bucillamine-induced nephrotic syndrome in patients with rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 1799186 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This paper describes pathological and clinical investigations of glomerular lesions in bucillamine-induced nephropathy by analyzing biopsy materials from 9 patients with rheumatoid arthritis (RA). There was no specific predisposition for nephrotic syndrome induced by bucillamine in clinical profiles related to age, onset, duration of disease, sex, activity and dose of bucillamine. In light-microscopic, electron-microscopic and immunofluorescent findings, the characteristic changes were similar to those of idiopathic membranous glomerulonephritis (MGN). After discontinuance of bucillamine, the nephrotic syndrome improved slowly with or without corticosteroid therapy. Results confirmed that the most common lesion of nephrotic syndrome associated with bucillamine therapy in RA is MGN. We recommend that corticosteroid therapy should be restricted to cases with severe proteinuria. |
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Authors:
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A Yoshida; K Morozumi; T Suganuma; K Sugito; M Ikeda; T Oikawa; T Fujinami; A Takeda; K Koyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of nephrology Volume: 11 ISSN: 0250-8095 ISO Abbreviation: Am. J. Nephrol. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-04-14 Completed Date: 1992-04-14 Revised Date: 2007-02-14 |
Medline Journal Info:
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Nlm Unique ID: 8109361 Medline TA: Am J Nephrol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 284-8 Citation Subset: IM |
Affiliation:
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Third Department of Internal Medicine, Nagoya City University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anti-Inflammatory Agents, Non-Steroidal
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adverse effects*,
therapeutic use Arthritis, Rheumatoid / drug therapy* Biopsy Cysteine / adverse effects, analogs & derivatives*, therapeutic use Female Fluorescent Antibody Technique Glomerulonephritis, Membranous / chemically induced*, diagnosis Humans Kidney / pathology Male Microscopy, Electron Middle Aged Nephrotic Syndrome / chemically induced*, diagnosis |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 52-90-4/Cysteine; 65002-17-7/bucillamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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