Document Detail


Clinicopathological features of serrated adenoma of the colorectum: comparison with traditional adenoma.
MedLine Citation:
PMID:  10605404     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: Serrated adenoma is a recently described category of colorectal adenoma. The aim of this study was to determine whether serrated adenomas have clinicopathological findings distinct from "traditional" adenoma. METHODS: Colonoscopy records for 1995-1998 were reviewed, and all traditional adenomas and serrated adenomas identified. Tumour site and endoscopic configuration were compared between the two types of adenoma. In polypectomised lesions, size and grade of dysplasia were compared between the two groups. RESULTS: There were 3305 traditional adenomas and 43 serrated adenomas. Serrated adenomas were more often found in the rectosigmoid colon than the traditional adenomas (67.5% v 41.2%, p = 0.0008). Polypectomy was more often done for serrated adenomas (27 of 43 lesions, 62.8%) than for traditional adenomas (626 of 3305 lesions, 18.9%, p < 0.0001). Size (mean (SD) maximum dimension, 12 (6) mm v 13 (3) mm) and incidence of high grade dysplasia (14.8% v 13.6%) in endoscopically removed specimens were not different between the two types. CONCLUSIONS: The therapeutic judgement applied to the management of traditional adenoma seems to be appropriate for serrated adenoma.
Authors:
T Matsumoto; M Mizuno; M Shimizu; T Manabe; M Iida
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of clinical pathology     Volume:  52     ISSN:  0021-9746     ISO Abbreviation:  J. Clin. Pathol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  2000-01-04     Completed Date:  2000-01-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0376601     Medline TA:  J Clin Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  513-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Kawasaki Medical School, Okayama, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / pathology*,  surgery
Chi-Square Distribution
Colonic Neoplasms / pathology*,  surgery
Colonoscopy
Colorectal Neoplasms / pathology*,  surgery
Female
Humans
Male
Middle Aged
Rectal Neoplasms / pathology,  surgery
Comments/Corrections

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