Document Detail

Clinicopathological features in misdiagnosed pancreatic carcinoma.
MedLine Citation:
PMID:  10576387     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: There is more potential for misclassification of adenocarcinoma of the pancreas than for many other cancers because of the difficulty of accurate diagnosis. METHODOLOGY: We analyzed the clinicopathological features of 105 patients who were suspected of having unresectable adenocarcinoma of the pancreas on their 1st visit to our outpatient clinic. RESULTS: Ten of 105 patients (10%) had been misdiagnosed as having pancreatic carcinoma. The final diagnoses were made mainly using dynamic computed tomography (CT) and/or histologic examination. The incidence of weight loss (> or = 7% of total-body weight, within 6 months before diagnosis) in the misdiagnosed patients was significantly lower than that in pancreatic carcinoma patients (30% vs. 67%, p=0.02). Serum CA19-9 abnormality (> 100 U/ml) was observed less frequently in the misdiagnosed patients than in the patients with pancreatic carcinoma (40% vs. 77%, p=0.01). The detection of a dilated main pancreatic duct and/or pancreatic mass by imaging modalities was less frequent in the misdiagnosed patients (p<0.01). CONCLUSIONS: Dynamic CT and/or histologic examination may be essential when making a definite diagnosis of advanced pancreatic carcinoma. In addition, weight loss, serum CA19-9 abnormality, detection of a dilated main pancreatic duct and/or pancreatic mass may also be useful in making a differential diagnosis of this disease.
H Nagahama; S Okada; T Okusaka; H Ishii; M Ikeda; H Nakasuka; M Yoshimori
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  46     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  2000-01-04     Completed Date:  2000-01-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GREECE    
Other Details:
Languages:  eng     Pagination:  2983-5     Citation Subset:  IM    
Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan.
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MeSH Terms
Adenocarcinoma / diagnosis,  pathology*
CA-19-9 Antigen / blood
Carcinoembryonic Antigen / blood
Diagnostic Errors
Pancreas / pathology
Pancreatic Elastase / blood
Pancreatic Neoplasms / diagnosis,  pathology*
Predictive Value of Tests
Tomography, X-Ray Computed
Weight Loss / physiology
Reg. No./Substance:
0/CA-19-9 Antigen; 0/Carcinoembryonic Antigen; EC Elastase

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