| Clinicopathological features in misdiagnosed pancreatic carcinoma. | |
| | |
MedLine Citation:
|
PMID: 10576387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/AIMS: There is more potential for misclassification of adenocarcinoma of the pancreas than for many other cancers because of the difficulty of accurate diagnosis. METHODOLOGY: We analyzed the clinicopathological features of 105 patients who were suspected of having unresectable adenocarcinoma of the pancreas on their 1st visit to our outpatient clinic. RESULTS: Ten of 105 patients (10%) had been misdiagnosed as having pancreatic carcinoma. The final diagnoses were made mainly using dynamic computed tomography (CT) and/or histologic examination. The incidence of weight loss (> or = 7% of total-body weight, within 6 months before diagnosis) in the misdiagnosed patients was significantly lower than that in pancreatic carcinoma patients (30% vs. 67%, p=0.02). Serum CA19-9 abnormality (> 100 U/ml) was observed less frequently in the misdiagnosed patients than in the patients with pancreatic carcinoma (40% vs. 77%, p=0.01). The detection of a dilated main pancreatic duct and/or pancreatic mass by imaging modalities was less frequent in the misdiagnosed patients (p<0.01). CONCLUSIONS: Dynamic CT and/or histologic examination may be essential when making a definite diagnosis of advanced pancreatic carcinoma. In addition, weight loss, serum CA19-9 abnormality, detection of a dilated main pancreatic duct and/or pancreatic mass may also be useful in making a differential diagnosis of this disease. |
| | |
Authors:
|
H Nagahama; S Okada; T Okusaka; H Ishii; M Ikeda; H Nakasuka; M Yoshimori |
Related Documents
:
|
21872357 - Antiphospholipid antibodies and atherosclerosis: insights from rheumatoid arthritis - a... 7992977 - Laparoscopic cholecystectomy in the inner-city hospital. 17882997 - Use of rk39 for diagnosis of post kala-azar dermal leishmaniasis in nepal. 12907327 - Incomplete response to endoscopic sphincterotomy in patients with sphincter of oddi dys... 9378387 - Rectal cell proliferation and colon cancer risk in patients with hypergastrinaemia. 17041377 - Are monoclonal gammopathies in rheumatoid arthritis predictive for lymphoproliferative ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Hepato-gastroenterology Volume: 46 ISSN: 0172-6390 ISO Abbreviation: Hepatogastroenterology Publication Date: 1999 Sep-Oct |
Date Detail:
|
Created Date: 2000-01-04 Completed Date: 2000-01-04 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8007849 Medline TA: Hepatogastroenterology Country: GREECE |
Other Details:
|
Languages: eng Pagination: 2983-5 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adenocarcinoma
/
diagnosis,
pathology* CA-19-9 Antigen / blood Carcinoembryonic Antigen / blood Diagnostic Errors Humans Pancreas / pathology Pancreatic Elastase / blood Pancreatic Neoplasms / diagnosis, pathology* Predictive Value of Tests Tomography, X-Ray Computed Weight Loss / physiology |
| Chemical | |
Reg. No./Substance:
|
0/CA-19-9 Antigen; 0/Carcinoembryonic Antigen; EC 3.4.21.36/Pancreatic Elastase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Solid papillary-cystic tumor of the pancreas.
Next Document: Severe acute pancreatitis associated with hyperlipidemia: report of two cases and review of the lite...