Document Detail


Clinicopathological features and immunohistochemical expression of p53, Ki-67, Mcm-2 and Mcm-5 in proliferative verrucous leukoplakia.
MedLine Citation:
PMID:  20412398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Proliferative verrucous leukoplakia (PVL) is a distinct and aggressive type of oral leukoplakia which affects elderly women without risk behavior and presents high rates of malignant transformation. The objective of the present study was to evaluate the clinicopathological characteristics and the distribution of cell proliferation markers, aiming to elucidate the distinct biological behavior of the PVL. METHODS: Clinical and microscopical features of 12 patients with PVL were reviewed. Immunohistochemical analysis for p53, Ki-67, Mcm-2 and Mcm-5 were performed and the data were correlated. RESULTS: All patients were women, above 50 years of age, 91.7% were non-smoker and 100% were non-habitual drinker. Alveolar ridge (66.6%), tongue (50%) and buccal mucosa (41.6%) were the most affected sites. Four patients developed squamous cell carcinoma (SCC). The immunohistochemical findings showed higher positivity for p53, Ki-67, Mcm-2 and Mcm-5 in SCCs. However, some patients with mild or moderate dysplasia, specially the patients who developed SCC, presented high expression of Mcm-2 and Mcm-5. CONCLUSIONS: High immunoexpression of Mcm-2 and Mcm-5 in mild and moderate dysplasia could be helpful to predict the malignant transformation of PVL.
Authors:
Adriele Ferreira Gouvêa; Pablo Agustin Vargas; Ricardo D Coletta; Jacks Jorge; Márcio Ajudarte Lopes
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Publication Detail:
Type:  Journal Article     Date:  2010-04-14
Journal Detail:
Title:  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology     Volume:  39     ISSN:  1600-0714     ISO Abbreviation:  J. Oral Pathol. Med.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-20     Completed Date:  2010-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911934     Medline TA:  J Oral Pathol Med     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  447-52     Citation Subset:  D; IM    
Affiliation:
Department of Oral Diagnosis, Oral Semiology and Pathology Section, Piracicaba Dental School, State University of Campinas, Piracicaba, Sao Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Carcinoma, Squamous Cell / pathology
Cell Cycle Proteins / biosynthesis
Cell Transformation, Neoplastic
Female
Humans
Immunoenzyme Techniques
Ki-67 Antigen / biosynthesis
Leukoplakia, Oral / metabolism*,  pathology
Middle Aged
Mouth Neoplasms / metabolism*,  pathology
Nuclear Proteins / biosynthesis
Tumor Markers, Biological / biosynthesis*
Tumor Suppressor Protein p53 / biosynthesis
Warts / metabolism*
Chemical
Reg. No./Substance:
0/Cell Cycle Proteins; 0/Ki-67 Antigen; 0/MCM2 protein, human; 0/MCM5 protein, human; 0/Nuclear Proteins; 0/Tumor Markers, Biological; 0/Tumor Suppressor Protein p53

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