| Clinicopathological features and immunohistochemical expression of p53, Ki-67, Mcm-2 and Mcm-5 in proliferative verrucous leukoplakia. | |
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MedLine Citation:
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PMID: 20412398 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Proliferative verrucous leukoplakia (PVL) is a distinct and aggressive type of oral leukoplakia which affects elderly women without risk behavior and presents high rates of malignant transformation. The objective of the present study was to evaluate the clinicopathological characteristics and the distribution of cell proliferation markers, aiming to elucidate the distinct biological behavior of the PVL. METHODS: Clinical and microscopical features of 12 patients with PVL were reviewed. Immunohistochemical analysis for p53, Ki-67, Mcm-2 and Mcm-5 were performed and the data were correlated. RESULTS: All patients were women, above 50 years of age, 91.7% were non-smoker and 100% were non-habitual drinker. Alveolar ridge (66.6%), tongue (50%) and buccal mucosa (41.6%) were the most affected sites. Four patients developed squamous cell carcinoma (SCC). The immunohistochemical findings showed higher positivity for p53, Ki-67, Mcm-2 and Mcm-5 in SCCs. However, some patients with mild or moderate dysplasia, specially the patients who developed SCC, presented high expression of Mcm-2 and Mcm-5. CONCLUSIONS: High immunoexpression of Mcm-2 and Mcm-5 in mild and moderate dysplasia could be helpful to predict the malignant transformation of PVL. |
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Authors:
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Adriele Ferreira Gouvêa; Pablo Agustin Vargas; Ricardo D Coletta; Jacks Jorge; Márcio Ajudarte Lopes |
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Publication Detail:
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Type: Journal Article Date: 2010-04-14 |
Journal Detail:
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Title: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology Volume: 39 ISSN: 1600-0714 ISO Abbreviation: J. Oral Pathol. Med. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-20 Completed Date: 2010-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8911934 Medline TA: J Oral Pathol Med Country: Denmark |
Other Details:
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Languages: eng Pagination: 447-52 Citation Subset: D; IM |
Affiliation:
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Department of Oral Diagnosis, Oral Semiology and Pathology Section, Piracicaba Dental School, State University of Campinas, Piracicaba, Sao Paulo, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Carcinoma, Squamous Cell / pathology Cell Cycle Proteins / biosynthesis Cell Transformation, Neoplastic Female Humans Immunoenzyme Techniques Ki-67 Antigen / biosynthesis Leukoplakia, Oral / metabolism*, pathology Middle Aged Mouth Neoplasms / metabolism*, pathology Nuclear Proteins / biosynthesis Tumor Markers, Biological / biosynthesis* Tumor Suppressor Protein p53 / biosynthesis Warts / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; 0/Ki-67 Antigen; 0/MCM2 protein, human; 0/MCM5 protein, human; 0/Nuclear Proteins; 0/Tumor Markers, Biological; 0/Tumor Suppressor Protein p53 |
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