| Clinicopathological features of human brainstem gliomas. | |
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MedLine Citation:
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PMID: 22484454 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We describe the clinicopathological features of 25 brainstem gliomas (BSGs). Twenty BSGs located in the pons and were all in children. Four BSGs located in the medulla oblongata were in 2 children and 2 adults. One (in a child) was located in the midbrain. Radiological findings on MR images were low-intensity on T1 weighted images and high-intensity on T2 weighted images. Mean survival when pontine glioma was treated by radiotherapy and/or use of temozolomide was 14 months, although 4 patients (3 cervicomedullary types and one focal type arising from midbrain) are alive. Follow up was from 5 months to 6 years. Histopathological features of 10 cases of the diffuse type were: 4 grade II astrocytomas, 4 grade III astrocytomas, and 2 glioblastomas. MIB-1 index was from 0.8 to 38 %. P53 was positive for 80 % of 15 tumors and there were no negative results. MGMT was positive in 60 % of 15 tumors and negative in 12.4 %. IDH1 was negative in 61.6 %. There was no positive result for IDH1 in this study. Thus, our histopathological results were indicative of high p53 immunoreactivity and no IDH1 immunoreactivity related to secondary malignant change. |
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Authors:
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Hidehiro Oka; Satoshi Utsuki; Yoshinori Tanizaki; Hiroyuki Hagiwara; Yoshiteru Miyajima; Kimitoshi Sato; Mari Kusumi; Chihiro Kijima; Kiyotaka Fujii |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-8 |
Journal Detail:
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Title: Brain tumor pathology Volume: - ISSN: 1861-387X ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9716507 Medline TA: Brain Tumor Pathol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minimi-ku, Sagamihara, Kanagawa, 225-318, Japan, okahiro@med.kitasato-u.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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