Document Detail

Clinicopathological features and genotype distribution in patients with hepatitis C virus chronic liver disease.
MedLine Citation:
PMID:  19696989     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Hepatitis C virus (HCV) genotype influences the severity of disease and response to therapy. This retrospective study examined the clinical and histological features and the genotype distribution in biopsied patients with HCV related chronic liver disease. METHODS: Of 105 biopsies from patients with HCV infection, 96 from patients with chronic liver disease were reviewed. The Ishak scoring system was used for histological analysis. RESULTS: Genotype 3 was most common accounting for 77.1%, and genotype 1 for 9.4% of cases. There was no significant association of transaminase levels, viral load or necro-inflammatory activity score with genotype. A severe degree of fibrosis was seen in 77.8% cases of genotype 1 and in 63.5% of genotype 3 (p=0.76). Variable degrees of steatosis were noted in 68.8% of cases. However, severe steatosis was noted only in genotype 3 (7 cases). Serum transaminase levels did not correlate with either histological activity (p=0.43) or degree of fibrosis (p=0.72). Severe fibrosis / cirrhosis was seen in 74.24% of patients above 40 years of age as compared to 33.3% of patients below 40 years (p=0.001). The frequency of Mallory hyaline was significantly different between genotypes 1 and 3 infection (P<0.001). CONCLUSIONS: This study confirms the preponderance of genotype 3 in Indian patients with HCV related chronic liver disease. Severe steatosis was seen only in genotype 3 and Mallory hyaline was very common in genotype 1. The small numbers of patients in non genotype 3 could be a reason for the apparent lack of histological differences between different HCV genotypes. Severe fibrosis seen in older age groups confirms that HCV infection is progressive and major acceleration of the disease process occurs after 40 years of age.
Rachel Abraham; Banumathi Ramakrishna; Avinash Balekuduru; Hubert Darius J Daniel; Priya Abraham; C Eapen Eapen; George Kurian
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2009-08-21
Journal Detail:
Title:  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology     Volume:  28     ISSN:  0975-0711     ISO Abbreviation:  Indian J Gastroenterol     Publication Date:    2009 Mar-Apr
Date Detail:
Created Date:  2009-08-21     Completed Date:  2010-03-04     Revised Date:  2010-06-16    
Medline Journal Info:
Nlm Unique ID:  8409436     Medline TA:  Indian J Gastroenterol     Country:  India    
Other Details:
Languages:  eng     Pagination:  53-8     Citation Subset:  IM    
Department of Pathology, Christian Medical College, Vellore, India.
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MeSH Terms
DNA, Viral / analysis*
Diagnosis, Differential
Disease Progression
Fatty Liver / epidemiology,  etiology,  pathology*
Hepacivirus / genetics*
Hepatitis C, Chronic / complications*,  pathology,  virology
India / epidemiology
Liver / pathology*,  virology
Liver Cirrhosis / epidemiology,  etiology,  pathology*
Middle Aged
Proteins / metabolism
Retrospective Studies
Severity of Illness Index
Transaminases / blood
Reg. No./Substance:
0/DNA, Viral; 0/Mallory body protein, human; 0/Proteins; EC 2.6.1.-/Transaminases

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