Document Detail

Clinicopathological features of gastric cancer cases and aberrantly expressed recoverin.
MedLine Citation:
PMID:  15065647     Owner:  NLM     Status:  MEDLINE    
Cancer-associated retinopathy (CAR) is an ocular manifestation of a paraneoplastic syndrome whereby immunological reactions toward recoverin, a retina-specific calcium binding protein, and other retinal antigens aberrantly expressed in tumor cells lead to the degeneration of retinal photoreceptor cells. Recently we reported that aberrant expression of recoverin was identified in more than 50% of tumor cells and their cell lines from several kinds of cancers, including gastric cancer, lung carcinoma, and other cancers. To elucidate the clinicopathological significance of aberrantly expressed recoverin in cancer cells, we performed immunocytochemical analysis using a monoclonal antibody against human recoverin. Within 18 patients with different clinical stages (I-IV) of gastric cancer, the aberrant expression of recoverin in tumor cells was recognized in 6 out of 18 patients (2 out of 2 stage IA, 1 out of 1 stage IB, 2 out of 3 stage II, 0 out of 7 stage IIIA, 0 out of 1 stage IIIB, and 1 out 4 stage IV). The present data are consistent in part with the previous observations that recoverin-expressing cancer cells induced tumor immunity and provide a favorable prognosis for primary cancer in CAR patients.
Hiroshi Ohguro; Hiroki Odagiri; Yasuhiro Miyagawa; Ikuyo Ohguro; Mutsuo Sasaki; Mitsuru Nakazawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  202     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-04-06     Completed Date:  2004-10-26     Revised Date:  2007-07-25    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  213-9     Citation Subset:  IM    
Departments of Ophthalmology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan.
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MeSH Terms
Antigens, Neoplasm / analysis*
Calcium-Binding Proteins / analysis*
Eye Diseases / etiology,  pathology
Eye Proteins / analysis*
Lipoproteins / analysis*
Retina / pathology
Stomach Neoplasms / chemistry*,  complications,  pathology*
Tumor Markers, Biological
Reg. No./Substance:
0/Antigens, Neoplasm; 0/Calcium-Binding Proteins; 0/Eye Proteins; 0/Lipoproteins; 0/RCVRN protein, human; 0/Tumor Markers, Biological; 135844-11-0/Recoverin

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