Document Detail


Clinicopathological features and HLA tissue typing in pemphigoid gestationis patients in Kuwait.
MedLine Citation:
PMID:  12780719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pemphigoid gestationis (PG) is a rare autoimmune disease of pregnancy. We report a series of 22 cases of PG in Kuwait. They constituted 18% of all the autoimmune bullous diseases registered in our centre over a span of 11 years. PG was observed to be the third most common bullous disease in our region. Ninety-five per cent of the patients were of Arab ethnicity. The clinical features observed in our patients were comparable to those reported elsewhere. Systemic steroids (prednisolone 20-60 mg daily) remained the mainstay of treatment to control the active disease and an optimal dose of 20 mg of prednisolone was maintained throughout the pregnancy and immediate postpartum period. We observed a favourable outcome of pregnancies complicated by PG without any associated maternal or foetal morbidity. Kuwaiti patients with PG were observed to have a predominance of HLA-DR3 and DQ2 antigens. No predominance of HLA-DR4 antigen was observed.
Authors:
A Nanda; K Al-Saeed; R Dvorak; I Al-Muzairai; H Al-Sabah; M Al-Arbash; Q A Alsaleh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental dermatology     Volume:  28     ISSN:  0307-6938     ISO Abbreviation:  Clin. Exp. Dermatol.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-06-03     Completed Date:  2003-08-14     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7606847     Medline TA:  Clin Exp Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  301-6     Citation Subset:  IM    
Affiliation:
As'ad Al-Hamad Dermatology Center, Al-Sabah Hospital, Kuwait. artinanda@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Autoimmune Diseases / drug therapy,  ethnology,  pathology*
Female
Glucocorticoids / therapeutic use
Histocompatibility Antigens Class II / analysis*
Histocompatibility Testing
Humans
Kuwait
Pemphigoid Gestationis / drug therapy,  ethnology,  pathology*
Prednisolone / therapeutic use
Pregnancy
Pregnancy Outcome
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Histocompatibility Antigens Class II; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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