Document Detail

Clinicopathological differences between hepatitis B viral genotype B- and C-related resectable hepatocellular carcinoma.
MedLine Citation:
PMID:  17212646     Owner:  NLM     Status:  MEDLINE    
Clinical and pathogenic differences exist between hepatitis B viral (HBV) genotypes B and C, and genotype C has a higher risk of hepatocellular carcinoma (HCC) development than genotype B. The aim of this study was to investigate whether HBV genotypes B and C influence the clinicopathological features of patients with resectable HCC. Stored serum samples from 193 patients with resectable HBV-related HCC were tested for HBV genotypes by a molecular method. Of 193 patients undergoing resection of HCC, 107 (55%) and 86 (45%) were infected with genotypes B and C, respectively. Compared with genotype C patients, genotype B patients were less likely to be associated with liver cirrhosis (33%vs 51%, P = 0.01). Pathologically, genotype B patients had a higher rate of solitary tumour (94%vs 86%, P = 0.048) and more satellite nodules (22%vs 12%, P = 0.05) than genotype C patients. Our results indicate that genotype B-related HCC is less associated with liver cirrhosis and has a higher frequency of solitary tumour as well as more satellite nodules than genotype C-related HCC. These characteristics may contribute to the recurrence patterns and prognosis of HBV-related HCC in patients with genotype B or C infection.
C-L Lin; J-D Chen; C-J Liu; P-H Lee; P-J Chen; M-Y Lai; J-H Kao; D-S Chen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of viral hepatitis     Volume:  14     ISSN:  1352-0504     ISO Abbreviation:  J. Viral Hepat.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-10     Completed Date:  2007-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435672     Medline TA:  J Viral Hepat     Country:  England    
Other Details:
Languages:  eng     Pagination:  64-9     Citation Subset:  IM    
Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan.
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MeSH Terms
Alanine Transaminase / blood
Bilirubin / blood
Carcinoma, Hepatocellular / blood,  pathology,  virology*
DNA, Viral / chemistry,  genetics
Hepatitis B virus / genetics*
Hepatitis B, Chronic / blood,  pathology,  virology*
Liver Neoplasms / blood,  pathology,  virology*
Middle Aged
Polymerase Chain Reaction
Prothrombin Time
Retrospective Studies
Serum Albumin / metabolism
alpha-Fetoproteins / metabolism
Reg. No./Substance:
0/DNA, Viral; 0/Serum Albumin; 0/alpha-Fetoproteins; 635-65-4/Bilirubin; EC Transaminase

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