| Clinicopathological differences between hepatitis B viral genotype B- and C-related resectable hepatocellular carcinoma. | |
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MedLine Citation:
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PMID: 17212646 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical and pathogenic differences exist between hepatitis B viral (HBV) genotypes B and C, and genotype C has a higher risk of hepatocellular carcinoma (HCC) development than genotype B. The aim of this study was to investigate whether HBV genotypes B and C influence the clinicopathological features of patients with resectable HCC. Stored serum samples from 193 patients with resectable HBV-related HCC were tested for HBV genotypes by a molecular method. Of 193 patients undergoing resection of HCC, 107 (55%) and 86 (45%) were infected with genotypes B and C, respectively. Compared with genotype C patients, genotype B patients were less likely to be associated with liver cirrhosis (33%vs 51%, P = 0.01). Pathologically, genotype B patients had a higher rate of solitary tumour (94%vs 86%, P = 0.048) and more satellite nodules (22%vs 12%, P = 0.05) than genotype C patients. Our results indicate that genotype B-related HCC is less associated with liver cirrhosis and has a higher frequency of solitary tumour as well as more satellite nodules than genotype C-related HCC. These characteristics may contribute to the recurrence patterns and prognosis of HBV-related HCC in patients with genotype B or C infection. |
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Authors:
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C-L Lin; J-D Chen; C-J Liu; P-H Lee; P-J Chen; M-Y Lai; J-H Kao; D-S Chen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of viral hepatitis Volume: 14 ISSN: 1352-0504 ISO Abbreviation: J. Viral Hepat. Publication Date: 2007 Jan |
Date Detail:
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Created Date: 2007-01-10 Completed Date: 2007-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9435672 Medline TA: J Viral Hepat Country: England |
Other Details:
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Languages: eng Pagination: 64-9 Citation Subset: IM |
Affiliation:
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Department of Gastroenterology, Ren-Ai Branch, Taipei City Hospital, Taipei, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Bilirubin / blood Carcinoma, Hepatocellular / blood, pathology, virology* DNA, Viral / chemistry, genetics Female Genotype Hepatitis B virus / genetics* Hepatitis B, Chronic / blood, pathology, virology* Humans Liver Neoplasms / blood, pathology, virology* Male Middle Aged Polymerase Chain Reaction Prothrombin Time Retrospective Studies Serum Albumin / metabolism alpha-Fetoproteins / metabolism |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/Serum Albumin; 0/alpha-Fetoproteins; 635-65-4/Bilirubin; EC 2.6.1.2/Alanine Transaminase |
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