Document Detail

Clinicopathological correlation of blistering diseases of skin.
MedLine Citation:
PMID:  19119539     Owner:  NLM     Status:  MEDLINE    
Blistering diseases are alarming skin conditions where blister formation occurs in various ways and cannot be differentiated clinically. For confirmation of diagnosis, along with routine histological examination, immunofluorescence study is essential. Tzanck smear may be used as a rapid diagnostic tool. We included here 34 cases of different blistering lesions. Other than routine Hematoxylin and Eosin stain, direct immunofluorescence test was done in 31 cases, indirect immunofluorescence in 28 cases and Tzanck smear in 33 cases. Direct immunofluorescence stain was also applied on Tzanck smears. The most frequent diagnoses were pemphigus (n = 16), bullous pemphigoid (n = 11) and linear IgA dermatosis (n = 3). Clinical findings and histological examination were sufficient for the diagnosis of most cases. Direct immunofluorescence study is essential in many cases, and indirect immunofluorescence study is a useful method for diagnosis of some of the blistering diseases, especially in pemphigus. Direct immunofluorescence staining on Tzanck smear is a novel technique for the diagnosis of pemphigus.
A K M Nurul Kabir; Mohammed Kamal; Aga Masood Choudhury
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Bangladesh Medical Research Council bulletin     Volume:  34     ISSN:  0377-9238     ISO Abbreviation:  Bangladesh Med Res Counc Bull     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607686     Medline TA:  Bangladesh Med Res Counc Bull     Country:  Bangladesh    
Other Details:
Languages:  eng     Pagination:  48-53     Citation Subset:  IM    
Department of Pathology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka 1000, Bangladesh.
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MeSH Terms
Autoimmune Diseases / diagnosis
Blister / diagnosis*,  etiology,  pathology
Child, Preschool
Fluorescent Antibody Technique, Direct
Middle Aged
Skin Diseases / diagnosis,  physiopathology*
Young Adult

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