Document Detail


Clinicopathological characteristics and outcomes of male lupus nephritis in China.
MedLine Citation:
PMID:  22898536     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective: The objective of this article is to assess clinicopathological characteristics and outcomes of patients with male lupus nephritis in a cohort of Chinese patients. Methods: Clinical, pathological and outcome data of lupus nephritis patients with different gender were retrospectively analyzed and compared. Results: Among 315 patients with renal biopsy-proven lupus nephritis, 45 were male and 270 were female. The average ages of disease onset of the male and female patients were comparable. The interval between presentation of lupus nephritis and diagnosis was significantly longer in the male group than in female group (p = 0.003). Clinical presentation was similar except that males had a significantly lower proportion of alopecia (p = 0.005). In laboratory data, male lupus nephritis patients had higher hemoglobin (p = 0.023) and higher serum creatinine (p < 0.001) than female patients. As for pathological classification and index, no significant difference was found between the two groups. The male patients presented with significantly lower ratios of complete remission and partial remission, and higher ratios of treatment failure and relapse than the female group. Regarding long-term survival and renal outcome, male patients had significantly worse prognosis than females (p = 0.005). Conclusions: The male lupus nephritis presented with later diagnosis, worse renal function, lower remission rate and higher relapse rate compared with female patients. The male patients had significantly higher mortality and poorer renal outcome.
Authors:
Y-F Wang; Y-X Xu; Y Tan; F Yu; M-H Zhao
Related Documents :
9270886 - Complement abnormalities with lower extremities discomfort in vietnamese immigrants.
18753706 - Association between body mass index and core components of metabolic syndrome in 1486 p...
22723456 - Kidney function and white matter disease in young stroke patients: analysis of the stro...
22675016 - Vibration therapy of the plantar fascia improves spasticity of the lower limbs of a pat...
3097256 - Effect of (-)deprenyl in long-term treatment of parkinson's disease. a 10-years experie...
1083916 - Immune reactivity in renal cancer: a sequential study.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-16
Journal Detail:
Title:  Lupus     Volume:  -     ISSN:  1477-0962     ISO Abbreviation:  Lupus     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204265     Medline TA:  Lupus     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Blood parameters and corneal-reflex of finishing pigs with and without lung affections observed post...
Next Document:  Depletion of CD4 T lymphocytes at the time of infection with M. avium subsp. paratuberculosis does n...