Document Detail


Clinicopathological characteristics and outcome of adult patients with hematuria and/or proteinuria found during routine examination.
MedLine Citation:
PMID:  16636583     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Patients with hematuria and/or proteinuria found during routine examination are commonly encountered. To define the clinicopathological characteristics and outcome of these patients, 142 patients with definite pathological diagnosis were studied retrospectively. METHODS: All the 142 patients were divided into three groups: pure hematuria (HU, n = 13), concomitant hematuria and proteinuria (HUPU, n = 79), and proteinuria alone (PU, n = 50). RESULTS: At the time of renal biopsy, 26% of the patients had renal insufficiency and 48% of the patients had hypertension. Pathologically, IgA nephropathy (n = 67) was the most common. A total of 51 patients were enrolled into the follow-up group. Finally, urinary abnormalities disappeared in 18% of the patients, 22% of HU developed proteinuria, 21% of HUPU and 23% of PU appeared to have a distinct increase of proteinuria, and 15% of PU developed hematuria. Seven patients with normal blood pressure before became hypertensive and 6% of the patients with normal renal function initially developed renal insufficiency. The renal outcome was associated with proteinuria and tubulointerstitial lesions. CONCLUSION: Because renal pathologic change does not always coincide with clinical manifestations, patients with hematuria and/or proteinuria found during routine examination do not necessarily imply a favorable outcome, so renal biopsy is quite important. Besides, early treatment and careful follow-up are helpful in these patients.
Authors:
Peicheng Shen; Xiaoqiang Ding; Jie Ten; Jun Ji; Jianzhou Zou; Yi Fang
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Publication Detail:
Type:  Journal Article     Date:  2006-04-24
Journal Detail:
Title:  Nephron. Clinical practice     Volume:  103     ISSN:  1660-2110     ISO Abbreviation:  Nephron Clin Pract     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-08-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101159763     Medline TA:  Nephron Clin Pract     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  c149-56     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel
Affiliation:
Department of Nephrology, Zhongshan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Creatinine / blood
Disease Progression
Female
Glomerulonephritis / diagnosis,  epidemiology
Hematuria / diagnosis*
Humans
Hypertension, Renal / diagnosis,  epidemiology
Kidney / pathology
Kidney Diseases / diagnosis*,  urine
Male
Middle Aged
Multivariate Analysis
Physical Examination
Prognosis
Proteinuria / diagnosis*,  therapy
Renal Insufficiency / diagnosis,  epidemiology
Retrospective Studies
Chemical
Reg. No./Substance:
60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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